Seroatlas · Human Serome Atlas

MFSD6L

Major facilitator superfamily domain-containing protein 6-like

Also known as: FLJ35773, MFS6L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IWD5
Gene: MFSD6L
Ensembl: ENSG00000185156
Chromosome: 17
Canonical length: 586 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

586 residues, UniProt reviewed canonical sequence.

>Q8IWD5|MFSD6L
     1  MSANPRWDIS RALGVAKLFH LVCGVREACV TPFLTLYLRQ LGLAAPWVGT LMGTKHLIAA
    61  FWAPVCAFLA KSYRKRRALL IGSLLGSVGA SLLMVLVPPV DKNRVHFPCN GSSGLTSTDA
   121  LPGVTLPVNI TSAQESASSH PAKRTAEVEM PGFRNPPGES DRETFRDLHV YLAPSVEGAR
   181  TTSQALLHPV TSGLKDHPWE VTFEVVKTAL PLLPGGKGPG NPANLSGTKG KAWAFDLSLE
   241  ALRRTFILSL GSVAFWELLT APLEQVADDS LYEFLDFVDA TDRYRSLWVW RLLGMSAGVC
   301  GITALVGQLD CFLMTSGPRG VVHFYGYSVV STLALLVSIA FPIPICQQWE PSYKRVKALS
   361  IVGGDPHLIL LASTTVLVGA IVSTVQNFLF WHMKDHGSGE LVMGFSVALS LLGEILLHPF
   421  KATLLRKLSR TGLVGLGLSC LAGQLLYYSF LWSWWSVLPI QILSAISNRA LWWAVGASVE
   481  DLATPRMERA LSALFRGHFY GSGCSLGSFV GGFVVMRFSL AVLYQACCVA LLLWLALLLS
   541  IQRRLPRERK IKYSKLLSME VSDTSDSEQG TEQDWLVKAM REEHSD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MFSD6L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 10
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

testis: 24 nTPM
pancreas: 8.8 nTPM
salivary gland: 6.4 nTPM
pituitary gland: 4.7 nTPM
parathyroid gland: 3.9 nTPM
stomach: 3.7 nTPM

Single-cell type

late primary spermatocytes: 151 nCPM
early spermatids: 124 nCPM
respiratory ionocytes: 61 nCPM
late spermatids: 55 nCPM
salivary ionocytes: 32 nCPM
lacrimal acinar cells: 12 nCPM

Immune cell

neutrophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

thalamus: 0.6 nTPM
basal ganglia: 0.4 nTPM
cerebral cortex: 0.4 nTPM
pons: 0.4 nTPM
white matter: 0.4 nTPM
medulla oblongata: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.21
gnomAD pLI: 0
gnomAD missense Z: -0.22
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MFSD6L as an antibody target. Whether an autoantibody or antibody against MFSD6L could matter depends on whether native MFSD6L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MFSD6L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MFSD6L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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