Seroatlas · Human Serome Atlas

MFSD6

Major facilitator superfamily domain-containing protein 6

Also known as: FLJ20160, MFSD6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZSS7
Gene: MFSD6
Ensembl: ENSG00000151690
Chromosome: 2
Canonical length: 791 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable MHC class I protein binding activity and MHC class I receptor activity. Predicted to be involved in antigen processing and presentation of exogenous peptide antigen via MHC class I. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

791 residues, UniProt reviewed canonical sequence.

>Q6ZSS7|MFSD6
     1  MADDKVAILT DDEEEQKRKY VLADPFNGIS REPEPPSNET PSSTETSAIP EEEIDWIEKH
    61  CVKINNDLLI SKVFYFFFYS AYGSLYPLLP VYYKQLGMSP SQSGLLVGIR YFIEFCSAPF
   121  WGVVADRFKK GKIVLLFSLL CWVLFNLGIG FVKPATLRCV PKIRPTTHPT NASHQLTILP
   181  TNSSFTSFLT ISPKMREKRN LLETRLNVSD TVTLPTAPNM NSEPTLQPQT GEITNRMMDL
   241  TLNSSTATPV SPGSVTKETT TVIVTTTKSL PSDQVMLVYD QQEVEAIFLV ILVVVIIGEF
   301  FSASSVTIVD TVTLQYLGKH RDRYGLQRMW GSLGWGLAML SVGIGIDYTH IEVLIDGKGC
   361  KPPEYRNYQI VFIVFGVLMT MALIVATQFR FRYNHFKNDD SKGKEVEIPQ VERNNSTESS
   421  EETPTTTSHS QAFNFWDLIK LLCSVQYGSV LFVAWFMGFG YGFVFTFLYW HLEDLNGTTT
   481  LFGVCSVLSH VSELTAYFFS HKLIELIGHI RVLYIGLACN TARYIYISYL ENAWTVLPME
   541  VLQGVTHAAI WAACISYLSA AVPPELRTSA QGILQGLHLG LGRGCGAMIG GVLVNYFGAA
   601  ATFRGIGMAC LVILLLFALI QWLAVPDEEE DKTMLAERIP VPSSPVPIAT IDLVQQQTED
   661  VMPRIEPRLP PKKTKHQEEQ EDVNKPAWGV SSSPWVTFVY ALYQIKEMMQ LTRDNRASEI
   721  QPLQGTNENR ENSPAGRAQP VPCETHSDPS RNQPSPDAAA SQTQTSPAHP SVDPCTEESE
   781  EQQAQLAAGG H

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MFSD6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 61 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 61 nTPM
spinal cord: 51 nTPM
cerebral cortex: 45 nTPM
midbrain: 44 nTPM
adrenal gland: 38 nTPM
esophagus: 38 nTPM

Single-cell type

corticotrophs: 283 nCPM
podocytes: 247 nCPM
somatotrophs: 191 nCPM
lactotrophs: 189 nCPM
respiratory ciliated cells: 160 nCPM
thyrotrophs: 157 nCPM

Immune cell

basophil: 4.6 nTPM
T-reg: 3.5 nTPM
NK-cell: 2.1 nTPM
memory CD8 T-cell: 2 nTPM
naive CD8 T-cell: 1.9 nTPM
memory CD4 T-cell: 1.8 nTPM

Brain region

pons: 141 nTPM
midbrain: 136 nTPM
white matter: 133 nTPM
medulla oblongata: 116 nTPM
cerebral cortex: 114 nTPM
thalamus: 111 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.82
gnomAD pLI: 0
gnomAD missense Z: 1.77
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

antigen processing and presentation of exogenous peptide antigen via MHC class I

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MFSD6 as an antibody target. Whether an autoantibody or antibody against MFSD6 could matter depends on whether native MFSD6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MFSD6 is annotated at the cell surface, where native MFSD6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MFSD6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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