Seroatlas · Human Serome Atlas

MFSD4B

Sodium-dependent glucose transporter 1

Also known as: KIAA1919, MFS4B_HUMAN, MGC33953, SLC60A2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5TF39
Gene: MFSD4B
Ensembl: ENSG00000173214
Chromosome: 6
Canonical length: 518 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Predicted to enable symporter activity. Predicted to be involved in sodium ion transport and transmembrane transport. Predicted to be located in apical plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

518 residues, UniProt reviewed canonical sequence.

>Q5TF39|MFSD4B
     1  MLCASFLGLG LSVAIVGPTF QDLATNVNRN ISSLSFIFVG RALGYLSGSV IGGFLVDVMN
    61  YFLLLGISMS ATTVGLYLVP FCKTAILLTV MMSIFGVSIG ILDTGGNVLI LAIWGDKGAP
   121  HMQALHFSFA LGAFLAPLLA KLALGPTASA ENHTESDFHP ALNQSSDADS EALFGVPNDK
   181  NLLWAYAVIG TYMFLVSVIF FCLFLKNSSK QEKARASAET FRRAKYHNAL LCLLFLFFFF
   241  YVGAEVTYGS YVFSFATTHA GMKESEAAGL NSIFWGTFAA CRGLAIFFAT CLQPGTMIVL
   301  SNIGSLTSSL FLVLFDKNPI CLWIATSVYG ASMATTFPSG VSWIEQYTTI HGKSAAFFVI
   361  GASLGEMAIP AVIGILQGKY PDLPVVLYTS LGASIATGIL FPVLYKLATS PLDRQRKEDR
   421  KSEDQKALLS SSGLNEYEEE NEEEDAEKWN EMDFEMIETN DTMRHSIIET SRSSLTEPTA
   481  EVYNQYPSNA LVFESSPFNT GSAHVKHLPE TRTKGTNV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MFSD4B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 4.4 nTPM

Expression across tissuesHPA

Tissue

placenta: 4.4 nTPM
testis: 4.1 nTPM
duodenum: 3.4 nTPM
small intestine: 3.2 nTPM
retina: 2.8 nTPM
kidney: 2.7 nTPM

Single-cell type

epicardial cells: 1,019 nCPM
endometrial stromal cells: 863 nCPM
cardiomyocytes: 796 nCPM
adipocytes: 628 nCPM
fibro-adipogenic progenitors: 505 nCPM
myonuclei: 469 nCPM

Immune cell

basophil: 4.2 nTPM
memory B-cell: 2.1 nTPM
MAIT T-cell: 2 nTPM
eosinophil: 1.9 nTPM
neutrophil: 1.9 nTPM
plasmacytoid DC: 1.8 nTPM

Brain region

choroid plexus: 23 nTPM
cerebellum: 12 nTPM
hypothalamus: 11 nTPM
basal ganglia: 11 nTPM
amygdala: 11 nTPM
cerebral cortex: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.13
gnomAD pLI: 0
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MFSD4B as an antibody target. Whether an autoantibody or antibody against MFSD4B could matter depends on whether native MFSD4B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MFSD4B is annotated at the cell surface, where native MFSD4B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MFSD4B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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