Seroatlas · Human Serome Atlas

MFSD3

Major facilitator superfamily domain-containing protein 3

Also known as: MFSD3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96ES6
Gene: MFSD3
Ensembl: ENSG00000167700
Chromosome: 8
Canonical length: 412 aa
Protein class: Predicted membrane proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

412 residues, UniProt reviewed canonical sequence.

>Q96ES6|MFSD3
     1  MRGKLLPLAG LYLVQGLPYG LQSGLLPVLL RAGGLSLTRV GLAKVLYAPW LLKLAWAPLV
    61  DAQGSARAWV TRSTAGLGLV CGLLAGLPPP GAGQAGLPAA VAGLLLLLNL GAAMQDVALD
   121  ALAVQLLEPA ELGPGNTVQV VAYKLGAALA GGALLALLPT FSWPQLFLLL AATYWLAAAL
   181  AWAAPALRRL PQQPPSEQRP HTAHLLRDVL AVPGTVWTAG FVLTYKLGEQ GASSLFPLLL
   241  LDHGVSAPEL GLWNGVGAVV CSIAGSSLGG TLLAKHWKLL PLLRSVLRFR LGGLACQTAL
   301  VFHLDTLGAS MDAGTILRGS ALLSLCLQHF LGGLVTTVTF TGMMRCSQLA PRALQATHYS
   361  LLATLELLGK LLLGTLAGGL ADGLGPHPCF LLLLILSAFP VLYLDLAPST FL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MFSD3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 11
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 44 nTPM

Expression across tissuesHPA

Tissue

liver: 44 nTPM
kidney: 26 nTPM
cerebral cortex: 23 nTPM
thyroid gland: 23 nTPM
skeletal muscle: 23 nTPM
adrenal gland: 22 nTPM

Single-cell type

epididymal principal cells: 64 nCPM
breast lactating cells: 54 nCPM
esophageal suprabasal cells: 47 nCPM
esophageal basal cells: 35 nCPM
colonocytes: 34 nCPM
hepatocytes: 34 nCPM

Immune cell

plasmacytoid DC: 19 nTPM
myeloid DC: 11 nTPM
classical monocyte: 7.4 nTPM
intermediate monocyte: 6.7 nTPM
memory B-cell: 4.9 nTPM
T-reg: 4.4 nTPM

Brain region

cerebral cortex: 32 nTPM
medulla oblongata: 32 nTPM
thalamus: 29 nTPM
pons: 29 nTPM
amygdala: 29 nTPM
hippocampal formation: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.85
gnomAD pLI: 0
gnomAD missense Z: -1.39
DepMap mean gene effect: -0.08
DepMap dependency class: selective

OntologyGO

Molecular functions

transmembrane transporter activity

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MFSD3 as an antibody target. Whether an autoantibody or antibody against MFSD3 could matter depends on whether native MFSD3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MFSD3 is annotated at the cell surface, where native MFSD3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MFSD3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...