Seroatlas · Human Serome Atlas

MFSD2B

Sphingosine-1-phosphate transporter MFSD2B

Also known as: MFS2B_HUMAN, SLC59A2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NFX1
Gene: MFSD2B
Ensembl: ENSG00000205639
Chromosome: 2
Canonical length: 504 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

Enables sphingolipid transporter activity. Involved in lipid transport. Is active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

504 residues, UniProt reviewed canonical sequence.

>A6NFX1|MFSD2B
     1  MAAPPAPAAK GSPQPEPHAP EPGPGSAKRG REDSRAGRLS FCTKVCYGIG GVPNQIASSA
    61  TAFYLQLFLL DIAQIPAAQV SLVLFGGKVS GAAADPVAGF FINRSQRTGS GRLMPWVLGC
   121  TPFIALAYFF LWFLPPFTSL RGLWYTTFYC LFQALATFFQ VPYTALTMLL TPCPRERDSA
   181  TAYRMTVEMA GTLMGATVHG LIVSGAHRPH RCEATATPGP VTVSPNAAHL YCIAAAVVVV
   241  TYPVCISLLC LGVKERPDPS APASGPGLSF LAGLSLTTRH PPYLKLVISF LFISAAVQVE
   301  QSYLVLFCTH ASQLHDHVQG LVLTVLVSAV LSTPLWEWVL QRFGKKTSAF GIFAMVPFAI
   361  LLAAVPTAPV AYVVAFVSGV SIAVSLLLPW SMLPDVVDDF QLQHRHGPGL ETIFYSSYVF
   421  FTKLSGACAL GISTLSLEFS GYKAGVCKQA EEVVVTLKVL IGAVPTCMIL AGLCILMVGS
   481  TPKTPSRDAS SRLSLRRRTS YSLA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MFSD2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 10
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 11 nTPM
placenta: 0.5 nTPM
spleen: 0.3 nTPM
testis: 0.3 nTPM
basal ganglia: 0.2 nTPM
lung: 0.2 nTPM

Single-cell type

platelets: 181 nCPM
erythrocyte progenitors: 88 nCPM
megakaryocyte-erythroid progenitors: 60 nCPM
megakaryocyte progenitors: 46 nCPM
megakaryocytes: 43 nCPM
cardiomyocytes: 43 nCPM

Immune cell

basophil: 2.9 nTPM
total PBMC: 1.3 nTPM
eosinophil: 0.5 nTPM
neutrophil: 0.2 nTPM
NK-cell: 0.1 nTPM
plasmacytoid DC: 0.1 nTPM

Brain region

cerebellum: 1.9 nTPM
basal ganglia: 1.8 nTPM
hypothalamus: 1.6 nTPM
cerebral cortex: 1.4 nTPM
amygdala: 1.3 nTPM
white matter: 1.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.21
gnomAD pLI: 0
gnomAD missense Z: 0.23
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MFSD2B as an antibody target. Whether an autoantibody or antibody against MFSD2B could matter depends on whether native MFSD2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MFSD2B is annotated at the cell surface, where native MFSD2B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MFSD2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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