Seroatlas · Human Serome Atlas

MFSD14B

Hippocampus abundant transcript-like protein 1

Also known as: FLJ14753, HIATL1, MF14B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5SR56
Gene: MFSD14B
Ensembl: ENSG00000148110
Chromosome: 9
Canonical length: 506 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

506 residues, UniProt reviewed canonical sequence.

>Q5SR56|MFSD14B
     1  MSVEPPPELE EKAASEPEAG AMPEKRAGAQ AAGSTWLQGF GRPSVYHAAI VIFLEFFAWG
    61  LLTTPMLTVL HETFSQHTFL MNGLIQGVKG LLSFLSAPLI GALSDVWGRK PFLLGTVFFT
   121  CFPIPLMRIS PWWYFAMISV SGVFSVTFSV IFAYVADVTQ EHERSTAYGW VSATFAASLV
   181  SSPAIGAYLS ASYGDSLVVL VATVVALLDI CFILVAVPES LPEKMRPVSW GAQISWKQAD
   241  PFASLKKVGK DSTVLLICIT VFLSYLPEAG QYSSFFLYLR QVIGFGSVKI AAFIAMVGIL
   301  SIVAQTAFLS ILMRSLGNKN TVLLGLGFQM LQLAWYGFGS QAWMMWAAGT VAAMSSITFP
   361  AISALVSRNA ESDQQGVAQG IITGIRGLCN GLGPALYGFI FYMFHVELTE LGPKLNSNNV
   421  PLQGAVIPGP PFLFGACIVL MSFLVALFIP EYSKASGVQK HSNSSSGSLT NTPERGSDED
   481  IEPLLQDSSI WELSSFEEPG NQCTEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MFSD14B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 90 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 90 nTPM
skin: 38 nTPM
esophagus: 37 nTPM
tonsil: 33 nTPM
urinary bladder: 32 nTPM
placenta: 31 nTPM

Single-cell type

neutrophil progenitors: 443 nCPM
neutrophils: 278 nCPM
esophageal apical cells: 161 nCPM
monocyte progenitors: 155 nCPM
melanocytes: 151 nCPM
urothelial cells: 110 nCPM

Immune cell

intermediate monocyte: 8.5 nTPM
neutrophil: 7.3 nTPM
myeloid DC: 6.2 nTPM
classical monocyte: 5.9 nTPM
non-classical monocyte: 5.9 nTPM
plasmacytoid DC: 5.1 nTPM

Brain region

choroid plexus: 46 nTPM
white matter: 36 nTPM
medulla oblongata: 34 nTPM
spinal cord: 33 nTPM
midbrain: 33 nTPM
basal ganglia: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.68
gnomAD pLI: 0
DepMap mean gene effect: -0.11
DepMap dependency class: selective

OntologyGO

Molecular functions

transmembrane transporter activity

Cellular components

endoplasmic reticulum membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MFSD14B as an antibody target. Whether an autoantibody or antibody against MFSD14B could matter depends on whether native MFSD14B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MFSD14B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MFSD14B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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