Seroatlas · Human Serome Atlas

MFSD14A

Hippocampus abundant transcript 1 protein

Also known as: DKFZP564L0864, HIAT1, MF14A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96MC6
Gene: MFSD14A
Ensembl: ENSG00000156875
Chromosome: 1
Canonical length: 490 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to act upstream of or within acrosome assembly; sperm mitochondrion organization; and spermatid nucleus differentiation. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

490 residues, UniProt reviewed canonical sequence.

>Q96MC6|MFSD14A
     1  MTQGKKKKRA ANRSIMLAKK IIIKDGGTPQ GIGSPSVYHA VIVIFLEFFA WGLLTAPTLV
    61  VLHETFPKHT FLMNGLIQGV KGLLSFLSAP LIGALSDVWG RKSFLLLTVF FTCAPIPLMK
   121  ISPWWYFAVI SVSGVFAVTF SVVFAYVADI TQEHERSMAY GLVSATFAAS LVTSPAIGAY
   181  LGRVYGDSLV VVLATAIALL DICFILVAVP ESLPEKMRPA SWGAPISWEQ ADPFASLKKV
   241  GQDSIVLLIC ITVFLSYLPE AGQYSSFFLY LRQIMKFSPE SVAAFIAVLG ILSIIAQTIV
   301  LSLLMRSIGN KNTILLGLGF QILQLAWYGF GSEPWMMWAA GAVAAMSSIT FPAVSALVSR
   361  TADADQQGVV QGMITGIRGL CNGLGPALYG FIFYIFHVEL KELPITGTDL GTNTSPQHHF
   421  EQNSIIPGPP FLFGACSVLL ALLVALFIPE HTNLSLRSSS WRKHCGSHSH PHNTQAPGEA
   481  KEPLLQDTNV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MFSD14A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 124 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 124 nTPM
bone marrow: 85 nTPM
smooth muscle: 33 nTPM
endometrium: 33 nTPM
testis: 33 nTPM
blood vessel: 33 nTPM

Single-cell type

oligodendrocytes: 24 nCPM
other brain neurons: 19 nCPM
epididymal basal cells: 16 nCPM
ependymal cells: 15 nCPM
epididymal clear cells: 14 nCPM
brain inhibitory neurons: 13 nCPM

Immune cell

neutrophil: 95 nTPM
basophil: 80 nTPM
total PBMC: 72 nTPM
T-reg: 61 nTPM
NK-cell: 60 nTPM
classical monocyte: 56 nTPM

Brain region

white matter: 39 nTPM
medulla oblongata: 35 nTPM
spinal cord: 32 nTPM
cerebellum: 31 nTPM
pons: 31 nTPM
hypothalamus: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.32
gnomAD pLI: 0.97
DepMap mean gene effect: -0.05
DepMap dependency class: selective

OntologyGO

Biological processes

Molecular functions

transmembrane transporter activity

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MFSD14A as an antibody target. Whether an autoantibody or antibody against MFSD14A could matter depends on whether native MFSD14A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MFSD14A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MFSD14A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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