Seroatlas · Human Serome Atlas

MFSD13A

Transmembrane protein 180

Also known as: bA18I14.8, C10orf77, FLJ22529, MF13A_HUMAN, TMEM180

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14CX5
Gene: MFSD13A
Ensembl: ENSG00000138111
Chromosome: 10
Canonical length: 517 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Golgi apparatus,Cytosol

OverviewNCBI Gene

Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

517 residues, UniProt reviewed canonical sequence.

>Q14CX5|MFSD13A
     1  MGLGQPQAWL LGLPTAVVYG SLALFTTILH NVFLLYYVDT FVSVYKINKM AFWVGETVFL
    61  LWNSLNDPLF GWLSDRQFLS SQPRSGAGLS SRAVVLARVQ ALGWHGPLLA LSFLAFWVPW
   121  APAGLQFLLC LCLYDGFLTL VDLHHHALLA DLALSAHDRT HLNFYCSLFS AAGSLSVFAS
   181  YAFWNKEDFS SFRAFCVTLA VSSGLGFLGA TQLLRRRVEA ARKDPGCSGL VVDSGLCGEE
   241  LLVGSEEADS ITLGRYLRQL ARHRNFLWFV SMDLVQVFHC HFNSNFFPLF LEHLLSDHIS
   301  LSTGSILLGL SYVAPHLNNL YFLSLCRRWG VYAVVRGLFL LKLGLSLLML LAGPDHLSLL
   361  CLFIASNRVF TEGTCKLLTL VVTDLVDEDL VLNHRKQAAS ALLFGMVALV TKPGQTFAPL
   421  LGTWLLCFYT GHDLFQQSLI TPVGSAHPWP EPPAPAPAQA PTLRQGCFYL LVLVPITCAL
   481  LQLFTWSQFT LHGRRLHMVK AQRQNLSQAQ TLDVKMV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MFSD13A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 17 nTPM
basal ganglia: 13 nTPM
cerebral cortex: 11 nTPM
skin: 11 nTPM
lung: 8.6 nTPM
hippocampal formation: 8.5 nTPM

Single-cell type

syncytiotrophoblasts: 58 nCPM
epicardial cells: 39 nCPM
alveolar cells type 2: 34 nCPM
tuft cells: 23 nCPM
transitional alveolar cells: 21 nCPM
neutrophil progenitors: 21 nCPM

Immune cell

myeloid DC: 4.5 nTPM
classical monocyte: 4.3 nTPM
eosinophil: 3.5 nTPM
memory B-cell: 3.5 nTPM
naive CD8 T-cell: 3.2 nTPM
intermediate monocyte: 3.1 nTPM

Brain region

cerebellum: 29 nTPM
basal ganglia: 27 nTPM
cerebral cortex: 24 nTPM
hippocampal formation: 23 nTPM
amygdala: 21 nTPM
thalamus: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.59
gnomAD pLI: 0.05
DepMap mean gene effect: -0.03
DepMap dependency class: selective

OntologyGO

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MFSD13A as an antibody target. Whether an autoantibody or antibody against MFSD13A could matter depends on whether native MFSD13A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MFSD13A is annotated at the cell surface, where native MFSD13A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MFSD13A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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