Seroatlas · Human Serome Atlas

MFSD11

UNC93-like protein MFSD11

Also known as: FLJ20226, FLJ22196, MFS11_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43934
Gene: MFSD11
Ensembl: ENSG00000092931
Chromosome: 17
Canonical length: 449 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

449 residues, UniProt reviewed canonical sequence.

>O43934|MFSD11
     1  MSPESKKLFN IIILGVAFMF MFTAFQTCGN VAQTVIRSLN RTDFHGSGYT SMAIIYGVFS
    61  ASNLITPSVV AIVGPQLSMF ASGLFYSMYI AVFIQPFPWS FYTASVFIGI AAAVLWTAQG
   121  NCLTINSDEH SIGRNSGIFW ALLQSSLFFG NLYIYFAWQG KTQISESDRR TVFIALTVIS
   181  LVGTVLFFLI RKPDSENVLG EDESSDDQDM EVNESAQNNL TKAVDAFKKS FKLCVTKEML
   241  LLSITTAYTG LELTFFSGVY GTCIGATNKF GAEEKSLIGL SGIFIGIGEI LGGSLFGLLS
   301  KNNRFGRNPV VLLGILVHFI AFYLIFLNMP GDAPIAPVKG TDSSAYIKSS KEVAILCSFL
   361  LGLGDSCFNT QLLSILGFLY SEDSAPAFAI FKFVQSICAA VAFFYSNYLL LHWQLLVMVI
   421  FGFFGTISFF TVEWEAAAFV ARGSDYRSI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MFSD11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 11
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 33 nTPM

Expression across tissuesHPA

Tissue

retina: 33 nTPM
skeletal muscle: 27 nTPM
testis: 21 nTPM
parathyroid gland: 20 nTPM
tongue: 20 nTPM
rectum: 19 nTPM

Single-cell type

cone photoreceptor cells: 371 nCPM
rod photoreceptor cells: 284 nCPM
myonuclei: 274 nCPM
early spermatids: 256 nCPM
late spermatids: 249 nCPM
cardiomyocytes: 235 nCPM

Immune cell

T-reg: 19 nTPM
intermediate monocyte: 18 nTPM
myeloid DC: 17 nTPM
neutrophil: 16 nTPM
memory CD8 T-cell: 16 nTPM
classical monocyte: 16 nTPM

Brain region

cerebellum: 37 nTPM
white matter: 35 nTPM
pons: 34 nTPM
cerebral cortex: 33 nTPM
thalamus: 32 nTPM
basal ganglia: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.86
gnomAD pLI: 0
gnomAD missense Z: 1.1
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MFSD11 as an antibody target. Whether an autoantibody or antibody against MFSD11 could matter depends on whether native MFSD11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MFSD11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MFSD11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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