Seroatlas · Human Serome Atlas

MFSD10

Major facilitator superfamily domain-containing protein 10

Also known as: IT10C3, MFS10_HUMAN, TETRAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14728
Gene: MFSD10
Ensembl: ENSG00000109736
Chromosome: 4
Canonical length: 455 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoplasm,Nuclear membrane

OverviewNCBI Gene

This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein likely functions in efflux of organic anions, including the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]

Canonical amino-acid sequenceUniProt

455 residues, UniProt reviewed canonical sequence.

>Q14728|MFSD10
     1  MGWGGGGGCT PRPPIHQQPP ERRVVTVVFL GLLLDLLAFT LLLPLLPGLL ESHGRAHDPL
    61  YGSWQGGVDW FATAIGMPVE KRYNSVLFGG LIGSAFSVLQ FLCAPLTGAT SDCLGRRPVM
   121  LLCLMGVATS YAVWATSRSF AAFLASRLIG GISKGNVSLS TAIVADLGSP LARSQGMAVI
   181  GVAFSLGFTL GPMLGASLPL EMAPWFALLF AASDLLFIFC FLPETLPLEK RAPSIALGFR
   241  DAADLLSPLA LLRFSAVARG QDPPSGDRLS SLRRLGLVYF LYLFLFSGLE YTLSFLTHQR
   301  FQFSSLQQGK MFFLIGLTMA TIQGAYARRI HPGGEVAAVK RALLLLVPAF LLIGWGRSLP
   361  VLGLGLLLYS FAAAVVVPCL SSVVAGYGSP GQKGTVMGTL RSLGALARAA GPLVAASVYW
   421  LAGAQACFTT WSGLFLLPFF LLQKLSYPAQ TLKAE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MFSD10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 11
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 62 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 62 nTPM
cerebellum: 41 nTPM
ovary: 40 nTPM
cervix: 38 nTPM
thyroid gland: 36 nTPM
lung: 36 nTPM

Single-cell type

extravillous trophoblasts: 134 nCPM
respiratory ciliated cells: 97 nCPM
syncytiotrophoblasts: 97 nCPM
breast myoepithelial cells: 90 nCPM
urothelial cells: 86 nCPM
fallopian tube ciliated cells: 86 nCPM

Immune cell

eosinophil: 118 nTPM
non-classical monocyte: 96 nTPM
memory CD8 T-cell: 82 nTPM
gdT-cell: 73 nTPM
intermediate monocyte: 71 nTPM
basophil: 65 nTPM

Brain region

choroid plexus: 34 nTPM
thalamus: 31 nTPM
medulla oblongata: 29 nTPM
cerebral cortex: 27 nTPM
amygdala: 27 nTPM
hippocampal formation: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.31
gnomAD pLI: 0
gnomAD missense Z: -0.75
DepMap mean gene effect: -0.02
DepMap dependency class: selective

OntologyGO

Biological processes

Molecular functions

organic anion transmembrane transporter activity
tetracycline transmembrane transporter activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MFSD10 as an antibody target. Whether an autoantibody or antibody against MFSD10 could matter depends on whether native MFSD10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MFSD10 is annotated at the cell surface, where native MFSD10 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MFSD10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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