Seroatlas · Human Serome Atlas

MFSD1

Lysosomal dipeptide transporter MFSD1

Also known as: FLJ14153, MFSD1_HUMAN, Minerva, UG0581B09

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H3U5
Gene: MFSD1
Ensembl: ENSG00000118855
Chromosome: 3
Canonical length: 465 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Plasma membrane,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables dipeptide uniporter activity. Involved in dipeptide transmembrane transport from lysosomal lumen to cytosol. Is active in lysosomal membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

465 residues, UniProt reviewed canonical sequence.

>Q9H3U5|MFSD1
     1  MEEEDEEARA LLAGGPDEAD RGAPAAPGAL PALCDPSRLA HRLLVLLLMC FLGFGSYFCY
    61  DNPAALQTQV KRDMQVNTTK FMLLYAWYSW PNVVLCFFGG FLIDRVFGIR WGTIIFSCFV
   121  CIGQVVFALG GIFNAFWLME FGRFVFGIGG ESLAVAQNTY AVSWFKGKEL NLVFGLQLSM
   181  ARIGSTVNMN LMGWLYSKIE ALLGSAGHTT LGITLMIGGI TCILSLICAL ALAYLDQRAE
   241  RILHKEQGKT GEVIKLTDVK DFSLPLWLIF IICVCYYVAV FPFIGLGKVF FTEKFGFSSQ
   301  AASAINSVVY VISAPMSPVF GLLVDKTGKN IIWVLCAVAA TLVSHMMLAF TMWNPWIAMC
   361  LLGLSYSLLA CALWPMVAFV VPEHQLGTAY GFMQSIQNLG LAIISIIAGM ILDSRGYLFL
   421  EVFFIACVSL SLLSVVLLYL VNRAQGGNLN YSARQREEIK FSHTE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MFSD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 46 nTPM

Expression across tissuesHPA

Tissue

esophagus: 46 nTPM
salivary gland: 46 nTPM
spleen: 40 nTPM
lung: 38 nTPM
urinary bladder: 37 nTPM
adipose tissue: 37 nTPM

Single-cell type

epicardial cells: 687 nCPM
platelets: 582 nCPM
kupffer cells: 578 nCPM
esophageal apical cells: 427 nCPM
macrophages: 316 nCPM
hofbauer cells: 287 nCPM

Immune cell

classical monocyte: 289 nTPM
myeloid DC: 255 nTPM
total PBMC: 252 nTPM
eosinophil: 247 nTPM
intermediate monocyte: 224 nTPM
non-classical monocyte: 189 nTPM

Brain region

choroid plexus: 79 nTPM
cerebellum: 70 nTPM
white matter: 65 nTPM
pons: 62 nTPM
medulla oblongata: 62 nTPM
thalamus: 62 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.25
gnomAD pLI: 0
gnomAD missense Z: -0.02
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein localization to lysosome
protein stabilization
dipeptide transmembrane transport from lysosomal lumen to cytosol

Molecular functions

protein homodimerization activity
dipeptide uniporter activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MFSD1 as an antibody target. Whether an autoantibody or antibody against MFSD1 could matter depends on whether native MFSD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MFSD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MFSD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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