Seroatlas · Human Serome Atlas

METTL9

Protein-L-histidine N-pros-methyltransferase

Also known as: DREV1, METL9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H1A3
Gene: METTL9
Ensembl: ENSG00000197006
Chromosome: 16
Canonical length: 318 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cell Junctions,Cytosol
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Enables protein-L-histidine N-pros-methyltransferase activity. Predicted to be involved in methylation. Is active in endoplasmic reticulum and mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

318 residues, UniProt reviewed canonical sequence.

>Q9H1A3|METTL9
     1  MRLLAGWLCL SLASVWLARR MWTLRSPLTR SLYVNMTSGP GGPAAAAGGR KENHQWYVCN
    61  REKLCESLQA VFVQSYLDQG TQIFLNNSIE KSGWLFIQLY HSFVSSVFSL FMSRTSINGL
   121  LGRGSMFVFS PDQFQRLLKI NPDWKTHRLL DLGAGDGEVT KIMSPHFEEI YATELSETMI
   181  WQLQKKKYRV LGINEWQNTG FQYDVISCLN LLDRCDQPLT LLKDIRSVLE PTRGRVILAL
   241  VLPFHPYVEN VGGKWEKPSE ILEIKGQNWE EQVNSLPEVF RKAGFVIEAF TRLPYLCEGD
   301  MYNDYYVLDD AVFVLKPV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against METTL9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 127 nTPM

Expression across tissuesHPA

Tissue

kidney: 127 nTPM
bone marrow: 110 nTPM
adrenal gland: 94 nTPM
skeletal muscle: 71 nTPM
basal ganglia: 68 nTPM
epididymis: 65 nTPM

Single-cell type

microglia: 122 nCPM
proximal tubule cells: 107 nCPM
renal connecting tubule cells: 99 nCPM
choroid plexus epithelial cells: 71 nCPM
renal collecting duct principal cells: 58 nCPM
ependymal cells: 56 nCPM

Immune cell

basophil: 112 nTPM
classical monocyte: 76 nTPM
myeloid DC: 43 nTPM
neutrophil: 36 nTPM
eosinophil: 33 nTPM
total PBMC: 29 nTPM

Brain region

choroid plexus: 67 nTPM
basal ganglia: 65 nTPM
white matter: 57 nTPM
spinal cord: 54 nTPM
thalamus: 54 nTPM
cerebral cortex: 52 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.45
gnomAD pLI: 0.8
gnomAD missense Z: 2.62
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

methylation

Molecular functions

protein-L-histidine N-pros-methyltransferase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

S-adenosyl-L-methionine-dependent methyltransferase superfamily
Protein-L-histidine N-pros-methyltransferase
DREV methyltransferase

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of METTL9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CANX

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads METTL9 as an antibody target. Whether an autoantibody or antibody against METTL9 could matter depends on whether native METTL9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

METTL9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label METTL9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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