Seroatlas · Human Serome Atlas

METTL27

Methyltransferase-like protein 27

Also known as: MET27_HUMAN, WBSCR27

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N6F8
Gene: METTL27
Ensembl: ENSG00000165171
Chromosome: 7
Canonical length: 245 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Mitochondria,Cytosol

OverviewNCBI Gene

This gene encodes a protein belonging to ubiE/COQ5 methyltransferase family. The gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.22-q11.23. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

245 residues, UniProt reviewed canonical sequence.

>Q8N6F8|METTL27
     1  MAQEEGGSLP EVRARVRAAH GIPDLAQKLH FYDRWAPDYD QDVATLLYRA PRLAVDCLTQ
    61  ALPGPPHSAL ILDVACGTGL VAAELRAPGF LQLHGVDGSP GMLEQAQAPG LYQRLSLCTL
   121  GQEPLPSPEG TFDAVLIVGA LSDGQVPCNA IPELHVTKPG GLVCLTTRTN SSNLQYKEAL
   181  EATLDRLEQA GMWEGLVAWP VDRLWTAGSW LPPSWRWYPA SLPRMASSPA LSTCTESGRR
   241  PRLRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against METTL27 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 19 nTPM
pancreas: 8.8 nTPM
kidney: 8.2 nTPM
parathyroid gland: 6.3 nTPM
fallopian tube: 5.4 nTPM
prostate: 5.1 nTPM

Single-cell type

epididymal efferent duct ciliated cells: 102 nCPM
respiratory ciliated cells: 89 nCPM
fallopian tube ciliated cells: 76 nCPM
endometrial ciliated cells: 64 nCPM
megakaryocytes: 50 nCPM
gastric progenitor cells: 45 nCPM

Immune cell

T-reg: 6.4 nTPM
intermediate monocyte: 2.2 nTPM
memory B-cell: 2.2 nTPM
eosinophil: 1.3 nTPM
myeloid DC: 1 nTPM
naive CD4 T-cell: 0.7 nTPM

Brain region

choroid plexus: 16 nTPM
cerebellum: 6.8 nTPM
midbrain: 6 nTPM
medulla oblongata: 4.7 nTPM
pons: 3.6 nTPM
amygdala: 3.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.02
gnomAD pLI: 0.06
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Williams-Beuren syndrome

InteractionsUniProt · HPA

Protein binding partners of METTL27 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PIK3R3

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads METTL27 as an antibody target. Whether an autoantibody or antibody against METTL27 could matter depends on whether native METTL27 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

METTL27 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label METTL27 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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