Seroatlas · Human Serome Atlas

METTL22

Methyltransferase-like protein 22

Also known as: C16orf68, FLJ12433, MET22_HUMAN, MGC2654

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BUU2
Gene: METTL22
Ensembl: ENSG00000067365
Chromosome: 16
Canonical length: 404 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli rim

OverviewNCBI Gene

This gene encodes a member of the non-histone lysine methyltransferases. It interacts with its substrate, Kin17, which is involved in DNA repair and replication and mRNA processing. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

404 residues, UniProt reviewed canonical sequence.

>Q9BUU2|METTL22
     1  MVQLAPAAAM DEVTFRSDTV LSDVHLYTPN HRHLMVRLNS VGQPVFLSQF KLLWSQDSWT
    61  DSGAKGGSHR DVHTKEPPSA ETGSTGSPPG SGHGNEGFSL QAGTDTTGQE VAEAQLDEDG
   121  DLDVVRRPRA ASDSNPAGPL RDKVHPMILA QEEDDVLGEE AQGSPHDIIR IEHTMATPLE
   181  DVGKQVWRGA LLLADYILFR QDLFRGCTAL ELGAGTGLAS IIAATMARTV YCTDVGADLL
   241  SMCQRNIALN SHLAATGGGI VRVKELDWLK DDLCTDPKVP FSWSQEEISD LYDHTTILFA
   301  AEVFYDDDLT DAVFKTLSRL AHRLKNACTA ILSVEKRLNF TLRHLDVTCE AYDHFRSCLH
   361  ALEQLADGKL RFVVEPVEAS FPQLLVYERL QQLELWKIIA EPVT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against METTL22 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 20 nTPM
testis: 14 nTPM
cerebellum: 13 nTPM
choroid plexus: 11 nTPM
retina: 9.7 nTPM
heart muscle: 8.9 nTPM

Single-cell type

late spermatids: 642 nCPM
late primary spermatocytes: 111 nCPM
early spermatids: 110 nCPM
platelets: 90 nCPM
megakaryocytes: 80 nCPM
kupffer cells: 62 nCPM

Immune cell

neutrophil: 9.7 nTPM
classical monocyte: 2.5 nTPM
myeloid DC: 2.3 nTPM
non-classical monocyte: 2.2 nTPM
eosinophil: 2 nTPM
intermediate monocyte: 1.9 nTPM

Brain region

cerebellum: 35 nTPM
cerebral cortex: 30 nTPM
pons: 29 nTPM
thalamus: 28 nTPM
medulla oblongata: 28 nTPM
white matter: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.35
gnomAD pLI: 0
gnomAD missense Z: -1.98
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein methylation

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Lysine methyltransferase
S-adenosyl-L-methionine-dependent methyltransferase superfamily
Lysine methyltransferase
Methyltransferase-like protein 22

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of METTL22 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads METTL22 as an antibody target. Whether an autoantibody or antibody against METTL22 could matter depends on whether native METTL22 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

METTL22 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label METTL22 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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