Seroatlas · Human Serome Atlas

KIN

DNA/RNA-binding protein KIN17

Also known as: KIN17, KIN17_HUMAN, Rts2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O60870
Gene
KIN
Ensembl
ENSG00000151657
Chromosome
10
Canonical length
393 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein, a characteristic shared by this human ortholog. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Canonical amino-acid sequenceUniProt

393 residues, UniProt reviewed canonical sequence.

>O60870|KIN
     1  MGKSDFLTPK AIANRIKSKG LQKLRWYCQM CQKQCRDENG FKCHCMSESH QRQLLLASEN
    61  PQQFMDYFSE EFRNDFLELL RRRFGTKRVH NNIVYNEYIS HREHIHMNAT QWETLTDFTK
   121  WLGREGLCKV DETPKGWYIQ YIDRDPETIR RQLELEKKKK QDLDDEEKTA KFIEEQVRRG
   181  LEGKEQEVPT FTELSRENDE EKVTFNLSKG ACSSSGATSS KSSTLGPSAL KTIGSSASVK
   241  RKESSQSSTQ SKEKKKKKSA LDEIMEIEEE KKRTARTDYW LQPEIIVKII TKKLGEKYHK
   301  KKAIVKEVID KYTAVVKMID SGDKLKLDQT HLETVIPAPG KRILVLNGGY RGNEGTLESI
   361  NEKTFSATIV IETGPLKGRR VEGIQYEDIS KLA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
3.4 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 3.4 nTPM
  • lymph node: 3.2 nTPM
  • retina: 3.2 nTPM
  • liver: 3.1 nTPM
  • skin: 3.1 nTPM
  • endometrium: 3 nTPM

Single-cell type

  • myonuclei: 79 nCPM
  • esophageal apical cells: 57 nCPM
  • oocytes: 55 nCPM
  • sertoli cells: 53 nCPM
  • lactotrophs: 49 nCPM
  • hofbauer cells: 48 nCPM

Immune cell

  • basophil: 16 nTPM
  • neutrophil: 8.7 nTPM
  • eosinophil: 7 nTPM
  • memory B-cell: 5.9 nTPM
  • plasmacytoid DC: 5.7 nTPM
  • naive B-cell: 5.4 nTPM

Brain region

  • cerebellum: 13 nTPM
  • cerebral cortex: 8.8 nTPM
  • white matter: 8.7 nTPM
  • hypothalamus: 7.9 nTPM
  • pons: 7.8 nTPM
  • thalamus: 7.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.73
gnomAD pLI
0
gnomAD missense Z
0.66
DepMap mean gene effect
-1.38
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Large ribosomal subunit protein uL2, domain 2
  • Zinc finger C2H2 superfamily
  • DNA/RNA-binding protein Kin17, WH-like domain
  • KIN17-like protein
  • DNA/RNA-binding protein KIN17, WH-like domain superfamily
  • KN17, SH3-like domain
  • Kin17, KOW domain
  • KIN17, C2H2-type zinc finger domain
  • KIN17 WH-like domain
  • KN17 SH3-like domain
  • KIN17 C-terminal SH3 domain
  • KIN17 C2H2-type zinc finger domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KIN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIN as an antibody target. Whether an autoantibody or antibody against KIN could matter depends on whether native KIN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

  • Originally selected based on protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein, a characteristic shared by this human ortholog.

Canonical record: https://seroatlas.com/gene/KIN. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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