Seroatlas · Human Serome Atlas

MEIKIN

Meiosis-specific kinetochore protein

Also known as: MEIKN_HUMAN, SPO13

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A087WXM9
Gene
MEIKIN
Ensembl
ENSG00000239642
Chromosome
5
Canonical length
373 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in meiotic chromosome segregation and meiotic sister chromatid cohesion. Predicted to be located in kinetochore. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

373 residues, UniProt reviewed canonical sequence.

>A0A087WXM9|MEIKIN
     1  MWPLRVYTRK KREGQRLNLT PTPDLGSPAK AEAPPGSKRK GKVHGLSKIA EKAERSRQGG
    61  SGSGPFSPRL GVTGEKSLQE NRSSEDTQDE KIASLRESVT DDLQVDSSSS NSELVSGLSL
   121  HHGMASSLLS YSVTDSYAEY KSFEESFPSP ELFRKSDYLD WECPNLEEHM QWKNSTLLDT
   181  SKAVAIEKAP QFSNVSAIFS TSSEDYQKCH RKTVMTVADQ NVSPKAKCAS NSESDNAACE
   241  ILLAEKTCPS TPEKTKKKKT NSSTPGKKNR GLLTSTPSSE TAGFVIDLSS VQKASFEELF
   301  PNVSNYVNSN EIVPVSSLQE NSSNEFPANA SEICCIIRTS PGTRQVKNKG VIVKKKKYSL
   361  PKDTPQDIII KMA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MEIKIN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.73
Highest tissue expression
5.5 nTPM

Expression across tissuesHPA

Tissue

  • testis: 5.5 nTPM
  • cerebral cortex: 0.7 nTPM
  • retina: 0.6 nTPM
  • amygdala: 0.5 nTPM
  • basal ganglia: 0.5 nTPM
  • cerebellum: 0.4 nTPM

Single-cell type

  • bergmann glia: 197 nCPM
  • astrocytes: 191 nCPM
  • oligodendrocyte progenitor cells: 36 nCPM
  • brain inhibitory neurons: 21 nCPM
  • brain excitatory neurons: 20 nCPM
  • early primary spermatocytes: 16 nCPM

Immune cell

  • non-classical monocyte: 0.7 nTPM
  • intermediate monocyte: 0.6 nTPM
  • myeloid DC: 0.3 nTPM
  • naive CD4 T-cell: 0.2 nTPM
  • classical monocyte: 0.1 nTPM
  • gdT-cell: 0.1 nTPM

Brain region

  • cerebral cortex: 1.6 nTPM
  • cerebellum: 1.3 nTPM
  • white matter: 1.1 nTPM
  • hippocampal formation: 0.9 nTPM
  • amygdala: 0.8 nTPM
  • thalamus: 0.8 nTPM

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Meiosis-specific kinetochore protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MEIKIN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MEIKIN as an antibody target. Whether an autoantibody or antibody against MEIKIN could matter depends on whether native MEIKIN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MEIKIN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MEIKIN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MEIKIN. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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