Seroatlas · Human Serome Atlas

MBD6

Methyl-CpG-binding domain protein 6

Also known as: KIAA1887, MBD6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96DN6
Gene: MBD6
Ensembl: ENSG00000166987
Chromosome: 12
Canonical length: 1003 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables chromatin binding activity. Located in chromocenter; fibrillar center; and nucleoplasm. Implicated in autism spectrum disorder. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1003 residues, UniProt reviewed canonical sequence.

>Q96DN6|MBD6
     1  MNGGNESSGA DRAGGPVATS VPIGWQRCVR EGAVLYISPS GTELSSLEQT RSYLLSDGTC
    61  KCGLECPLNV PKVFNFDPLA PVTPGGAGVG PASEEDMTKL CNHRRKAVAM ATLYRSMETT
   121  CSHSSPGEGA SPQMFHTVSP GPPSARPPCR VPPTTPLNGG PGSLPPEPPS VSQAFPTLAG
   181  PGGLFPPRLA DPVPSGGSSS PRFLPRGNAP SPAPPPPPAI SLNAPSYNWG AALRSSLVPS
   241  DLGSPPAPHA SSSPPSDPPL FHCSDALTPP PLPPSNNLPA HPGPASQPPV SSATMHLPLV
   301  LGPLGGAPTV EGPGAPPFLA SSLLSAAAKA QHPPLPPPST LQGRRPRAQA PSASHSSSLR
   361  PSQRRPRRPP TVFRLLEGRG PQTPRRSRPR APAPVPQPFS LPEPSQPILP SVLSLLGLPT
   421  PGPSHSDGSF NLLGSDAHLP PPPTLSSGSP PQPRHPIQPS LPGTTSGSLS SVPGAPAPPA
   481  ASKAPVVPSP VLQSPSEGLG MGAGPACPLP PLAGGEAFPF PSPEQGLALS GAGFPGMLGA
   541  LPLPLSLGQP PPSPLLNHSL FGVLTGGGGQ PPPEPLLPPP GGPGPPLAPG EPEGPSLLVA
   601  SLLPPPPSDL LPPPSAPPSN LLASFLPLLA LGPTAGDGEG SAEGAGGPSG EPFSGLGDLS
   661  PLLFPPLSAP PTLIALNSAL LAATLDPPSG TPPQPCVLSA PQPGPPTSSV TTATTDPGAS
   721  SLGKAPSNSG RPPQLLSPLL GASLLGDLSS LTSSPGALPS LLQPPGPLLS GQLGLQLLPG
   781  GGAPPPLSEA SSPLACLLQS LQIPPEQPEA PCLPPESPAS ALEPEPARPP LSALAPPHGS
   841  PDPPVPELLT GRGSGKRGRR GGGGLRGING EARPARGRKP GSRREPGRLA LKWGTRGGFN
   901  GQMERSPRRT HHWQHNGELA EGGAEPKDPP PPGPHSEDLK VPPGVVRKSR RGRRRKYNPT
   961  RNSNSSRQDI TLEPSPTARA AVPLPPRARP GRPAKNKRRK LAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MBD6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.71
Highest tissue expression: 103 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 103 nTPM
pituitary gland: 96 nTPM
spleen: 59 nTPM
testis: 54 nTPM
bone marrow: 54 nTPM
endometrium: 45 nTPM

Single-cell type

neutrophils: 194 nCPM
platelets: 64 nCPM
early primary spermatocytes: 59 nCPM
tuft cells: 58 nCPM
neutrophil progenitors: 54 nCPM
pituicytes/fscs: 51 nCPM

Immune cell

neutrophil: 14 nTPM
gdT-cell: 1.3 nTPM
memory B-cell: 1.3 nTPM
classical monocyte: 1 nTPM
intermediate monocyte: 0.9 nTPM
naive B-cell: 0.8 nTPM

Brain region

white matter: 53 nTPM
thalamus: 50 nTPM
medulla oblongata: 49 nTPM
cerebral cortex: 47 nTPM
hypothalamus: 45 nTPM
choroid plexus: 44 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.21
gnomAD pLI: 1
gnomAD missense Z: -0.74
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

chromatin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MBD6 as an antibody target. Whether an autoantibody or antibody against MBD6 could matter depends on whether native MBD6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MBD6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MBD6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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