MAP3K11

Protein identityUniProt · HPA

UniProt accession

Q16584

Gene

MAP3K11

Ensembl

ENSG00000173327

Chromosome

11

Canonical length

847 aa

Protein class

Enzymes, Predicted intracellular proteins

Subcellular location

Centriolar satellite,Cytosol

Quaternary structure

Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

847 residues, UniProt reviewed canonical sequence.

>Q16584|MAP3K11
     1  MEPLKSLFLK SPLGSWNGSG SGGGGGGGGG RPEGSPKAAG YANPVWTALF DYEPSGQDEL
    61  ALRKGDRVEV LSRDAAISGD EGWWAGQVGG QVGIFPSNYV SRGGGPPPCE VASFQELRLE
   121  EVIGIGGFGK VYRGSWRGEL VAVKAARQDP DEDISVTAES VRQEARLFAM LAHPNIIALK
   181  AVCLEEPNLC LVMEYAAGGP LSRALAGRRV PPHVLVNWAV QIARGMHYLH CEALVPVIHR
   241  DLKSNNILLL QPIESDDMEH KTLKITDFGL AREWHKTTQM SAAGTYAWMA PEVIKASTFS
   301  KGSDVWSFGV LLWELLTGEV PYRGIDCLAV AYGVAVNKLT LPIPSTCPEP FAQLMADCWA
   361  QDPHRRPDFA SILQQLEALE AQVLREMPRD SFHSMQEGWK REIQGLFDEL RAKEKELLSR
   421  EEELTRAARE QRSQAEQLRR REHLLAQWEL EVFERELTLL LQQVDRERPH VRRRRGTFKR
   481  SKLRARDGGE RISMPLDFKH RITVQASPGL DRRRNVFEVG PGDSPTFPRF RAIQLEPAEP
   541  GQAWGRQSPR RLEDSSNGER RACWAWGPSS PKPGEAQNGR RRSRMDEATW YLDSDDSSPL
   601  GSPSTPPALN GNPPRPSLEP EEPKRPVPAE RGSSSGTPKL IQRALLRGTA LLASLGLGRD
   661  LQPPGGPGRE RGESPTTPPT PTPAPCPTEP PPSPLICFSL KTPDSPPTPA PLLLDLGIPV
   721  GQRSAKSPRR EEEPRGGTVS PPPGTSRSAP GTPGTPRSPP LGLISRPRPS PLRSRIDPWS
   781  FVSAGPRPSP LPSPQPAPRR APWTLFPDSD PFWDSPPANP FQGGPQDCRA QTKDMGAQAP
   841  WVPEAGP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAP3K11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.51

Highest tissue expression

93 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MAP3K11.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 128 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Moyamoya angiopathy

Disease | ImmuneIEDB

Conditions an epitope on MAP3K11 was assayed in.

• narcolepsy B cell
• multiple sclerosis B cell
• peripheral nervous system disease B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.48

gnomAD pLI

0.01

gnomAD missense Z

1.9

DepMap mean gene effect

-0.23

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell cycle G1/S phase transition
• JNK cascade
• MAPK cascade
• microtubule-based process
• positive regulation of JNK cascade
• positive regulation of JUN kinase activity
• positive regulation of neuron apoptotic process
• protein autophosphorylation
• protein phosphorylation

Molecular functions

• ATP binding
• identical protein binding
• JUN kinase kinase kinase activity
• MAP kinase kinase kinase activity
• mitogen-activated protein kinase kinase binding
• mitogen-activated protein kinase kinase kinase binding
• protein homodimerization activity
• protein kinase activity
• protein serine kinase activity
• protein serine/threonine kinase activity
• small GTPase binding

Cellular components

• centrosome
• cytoplasm
• cytosol
• membrane
• microtubule

Protein domainsUniProt · Pfam · InterPro

• Protein kinase domain
• Serine-threonine/tyrosine-protein kinase, catalytic domain
• SH3 domain
• Serine/threonine-protein kinase, active site
• Protein kinase-like domain superfamily
• Mitogen-activated protein (MAP) kinase kinase kinase, MLK1-4
• Protein kinase, ATP binding site
• MLK1-3, SH3 domain
• SH3-like domain superfamily
• Serine/Threonine Kinases and Pseudokinases
• Protein tyrosine and serine/threonine kinase
• Variant SH3 domain

KeywordsUniProt

• ATP-binding
• Cytoplasm
• Cytoskeleton
• Kinase
• Nucleotide-binding
• Phosphoprotein
• Repeat
• Serine/threonine-protein kinase
• SH3 domain
• Transferase

InteractionsUniProt · HPA

Protein binding partners of MAP3K11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CDC42