MAOB

Protein identityUniProt · HPA

UniProt accession

P27338

Gene

MAOB

Ensembl

ENSG00000069535

Chromosome

X

Canonical length

520 aa

Protein class

Enzymes, FDA approved drug targets, Metabolic proteins, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous sysytem and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

520 residues, UniProt reviewed canonical sequence.

>P27338|MAOB
     1  MSNKCDVVVV GGGISGMAAA KLLHDSGLNV VVLEARDRVG GRTYTLRNQK VKYVDLGGSY
    61  VGPTQNRILR LAKELGLETY KVNEVERLIH HVKGKSYPFR GPFPPVWNPI TYLDHNNFWR
   121  TMDDMGREIP SDAPWKAPLA EEWDNMTMKE LLDKLCWTES AKQLATLFVN LCVTAETHEV
   181  SALWFLWYVK QCGGTTRIIS TTNGGQERKF VGGSGQVSER IMDLLGDRVK LERPVIYIDQ
   241  TRENVLVETL NHEMYEAKYV ISAIPPTLGM KIHFNPPLPM MRNQMITRVP LGSVIKCIVY
   301  YKEPFWRKKD YCGTMIIDGE EAPVAYTLDD TKPEGNYAAI MGFILAHKAR KLARLTKEER
   361  LKKLCELYAK VLGSLEALEP VHYEEKNWCE EQYSGGCYTT YFPPGILTQY GRVLRQPVDR
   421  IYFAGTETAT HWSGYMEGAV EAGERAAREI LHAMGKIPED EIWQSEPESV DVPAQPITTT
   481  FLERHLPSVP GLLRLIGLTT IFSATALGFL AHKRGLLVRV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAOB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.22

Highest tissue expression

297 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.15

gnomAD pLI

1

gnomAD missense Z

1.75

DepMap mean gene effect

0.02

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• dopamine catabolic process
• hydrogen peroxide biosynthetic process
• substantia nigra development

Molecular functions

• electron transfer activity
• flavin adenine dinucleotide binding
• monoamine oxidase activity
• primary methylamine oxidase activity

Cellular components

• mitochondrial envelope
• mitochondrial outer membrane
• mitochondrion

Protein domainsUniProt · Pfam · InterPro

• Flavin amine oxidase
• Amine oxidase
• FAD/NAD(P)-binding domain superfamily
• Flavin Monoamine Oxidase
• Flavin containing amine oxidoreductase

KeywordsUniProt

• Acetylation
• FAD
• Flavoprotein
• Membrane
• Mitochondrion
• Mitochondrion outer membrane
• Oxidoreductase
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of MAOB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MAOA