MAOA

Protein identityUniProt · HPA

UniProt accession

P21397

Gene

MAOA

Ensembl

ENSG00000189221

Chromosome

X

Canonical length

527 aa

Protein class

Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins

Subcellular location

Mitochondria,Cytosol

OverviewNCBI Gene

This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

527 residues, UniProt reviewed canonical sequence.

>P21397|MAOA
     1  MENQEKASIA GHMFDVVVIG GGISGLSAAK LLTEYGVSVL VLEARDRVGG RTYTIRNEHV
    61  DYVDVGGAYV GPTQNRILRL SKELGIETYK VNVSERLVQY VKGKTYPFRG AFPPVWNPIA
   121  YLDYNNLWRT IDNMGKEIPT DAPWEAQHAD KWDKMTMKEL IDKICWTKTA RRFAYLFVNI
   181  NVTSEPHEVS ALWFLWYVKQ CGGTTRIFSV TNGGQERKFV GGSGQVSERI MDLLGDQVKL
   241  NHPVTHVDQS SDNIIIETLN HEHYECKYVI NAIPPTLTAK IHFRPELPAE RNQLIQRLPM
   301  GAVIKCMMYY KEAFWKKKDY CGCMIIEDED APISITLDDT KPDGSLPAIM GFILARKADR
   361  LAKLHKEIRK KKICELYAKV LGSQEALHPV HYEEKNWCEE QYSGGCYTAY FPPGIMTQYG
   421  RVIRQPVGRI FFAGTETATK WSGYMEGAVE AGERAAREVL NGLGKVTEKD IWVQEPESKD
   481  VPAVEITHTF WERNLPSVSG LLKIIGFSTS VTALGFVLYK YKLLPRS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAOA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.22

Highest tissue expression

206 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MAOA.

Disease | AllUniProt

Conditions MAOA is implicated in, by any mechanism.

• Brunner syndrome (BRNRS) MIM:300615

Disease | GeneticClinVar

20 pathogenic / likely-pathogenic of 330 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Brunner syndrome
• Inborn genetic diseases
• Autism, severe
• Antisocial behavior, susceptibility to
• Intellectual disability

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.14

gnomAD pLI

1

gnomAD missense Z

2.38

DepMap mean gene effect

0.13

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• biogenic amine metabolic process
• dopamine catabolic process
• positive regulation of signal transduction
• serotonin catabolic process

Molecular functions

• flavin adenine dinucleotide binding
• monoamine oxidase activity
• primary methylamine oxidase activity

Cellular components

• cytosol
• mitochondrial outer membrane
• mitochondrion

Protein domainsUniProt · Pfam · InterPro

• Flavin amine oxidase
• Amine oxidase
• FAD/NAD(P)-binding domain superfamily
• Flavin Monoamine Oxidase
• Flavin containing amine oxidoreductase

KeywordsUniProt

• Acetylation
• Catecholamine metabolism
• FAD
• Flavoprotein
• Intellectual disability
• Membrane
• Mitochondrion
• Mitochondrion outer membrane
• Neurotransmitter degradation
• Oxidoreductase
• Phosphoprotein
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of MAOA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MAOB