Seroatlas · Human Serome Atlas

MAGEA5P

Putative melanoma-associated antigen 5P

Also known as: MAGA5_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P43359
Gene: MAGEA5P
Canonical length: 124 aa

OverviewNCBI Gene

No narrative summary is available for MAGEA5P in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

124 residues, UniProt reviewed canonical sequence.

>P43359|MAGEA5P
     1  MSLEQKSQHC KPEEGLDTQE EALGLVGVQA ATTEEQEAVS SSSPLVPGTL GEVPAAGSPG
    61  PLKSPQGASA IPTAIDFTLW RQSIKGSSNQ EEEGPSTSPD PESVFRAALS KKVADLIHFL
   121  LLKY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAGEA5P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67

OntologyGO

Biological processes

regulation of chromosome segregation

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Tumor antigen

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAGEA5P as an antibody target. Whether an autoantibody or antibody against MAGEA5P could matter depends on whether native MAGEA5P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAGEA5P is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAGEA5P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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