Seroatlas · Human Serome Atlas

LXN

Latexin

Also known as: LXN_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BS40
Gene: LXN
Ensembl: ENSG00000079257
Chromosome: 3
Canonical length: 222 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes the only known protein inhibitor of zinc-dependent metallocarboxypeptidases. The encoded protein, latexin, downregulates the population size of hematopoietic stem cells. This protein is found to be downregulated in cancer cells because of promoter hypermethylation. [provided by RefSeq, Jul 2020]

Canonical amino-acid sequenceUniProt

222 residues, UniProt reviewed canonical sequence.

>Q9BS40|LXN
     1  MEIPPTNYPA SRAALVAQNY INYQQGTPHR VFEVQKVKQA SMEDIPGRGH KYHLKFAVEE
    61  IIQKQVKVNC TAEVLYPSTG QETAPEVNFT FEGETGKNPD EEDNTFYQRL KSMKEPLEAQ
   121  NIPDNFGNVS PEMTLVLHLA WVACGYIIWQ NSTEDTWYKM VKIQTVKQVQ RNDDFIELDY
   181  TILLHNIASQ EIIPWQMQVL WHPQYGTKVK HNSRLPKEVQ LE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LXN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 91 nTPM

Expression across tissuesHPA

Tissue

urinary bladder: 91 nTPM
adipose tissue: 58 nTPM
adrenal gland: 47 nTPM
salivary gland: 42 nTPM
rectum: 41 nTPM
ovary: 41 nTPM

Single-cell type

prostatic club cells: 250 nCPM
mesothelial cells: 203 nCPM
fallopian tube ciliated cells: 196 nCPM
respiratory ciliated cells: 137 nCPM
conjunctival goblet cells: 136 nCPM
platelets: 131 nCPM

Immune cell

neutrophil: 37 nTPM
T-reg: 30 nTPM
basophil: 29 nTPM
naive CD4 T-cell: 13 nTPM
memory CD4 T-cell: 12 nTPM
memory B-cell: 10 nTPM

Brain region

choroid plexus: 30 nTPM
cerebellum: 16 nTPM
cerebral cortex: 14 nTPM
hypothalamus: 14 nTPM
hippocampal formation: 10 nTPM
midbrain: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.36
gnomAD pLI: 0
gnomAD missense Z: 0.75
DepMap mean gene effect: 0.19
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LXN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CPA4

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LXN as an antibody target. Whether an autoantibody or antibody against LXN could matter depends on whether native LXN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LXN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LXN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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