CPA4

Protein identityUniProt · HPA

UniProt accession

Q9UI42

Gene

CPA4

Ensembl

ENSG00000128510

Chromosome

7

Canonical length

421 aa

Protein class

Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins

Subcellular location

Nucleoplasm,Plasma membrane,Centriolar satellite

Secretome location

Secreted in other tissues

OverviewNCBI Gene

This gene is a member of the carboxypeptidase A/B subfamily, and it is located in a cluster with three other family members on chromosome 7. Carboxypeptidases are zinc-containing exopeptidases that catalyze the release of carboxy-terminal amino acids, and are synthesized as zymogens that are activated by proteolytic cleavage. This gene could be involved in the histone hyperacetylation pathway. It is imprinted and may be a strong candidate gene for prostate cancer aggressiveness. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

421 residues, UniProt reviewed canonical sequence.

>Q9UI42|CPA4
     1  MRWILFIGAL IGSSICGQEK FFGDQVLRIN VRNGDEISKL SQLVNSNNLK LNFWKSPSSF
    61  NRPVDVLVPS VSLQAFKSFL RSQGLEYAVT IEDLQALLDN EDDEMQHNEG QERSSNNFNY
   121  GAYHSLEAIY HEMDNIAADF PDLARRVKIG HSFENRPMYV LKFSTGKGVR RPAVWLNAGI
   181  HSREWISQAT AIWTARKIVS DYQRDPAITS ILEKMDIFLL PVANPDGYVY TQTQNRLWRK
   241  TRSRNPGSSC IGADPNRNWN ASFAGKGASD NPCSEVYHGP HANSEVEVKS VVDFIQKHGN
   301  FKGFIDLHSY SQLLMYPYGY SVKKAPDAEE LDKVARLAAK ALASVSGTEY QVGPTCTTVY
   361  PASGSSIDWA YDNGIKFAFT FELRDTGTYG FLLPANQIIP TAEETWLGLK TIMEHVRDNL
   421  Y

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CPA4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.23

Highest tissue expression

54 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.4

gnomAD pLI

0

gnomAD missense Z

0.53

DepMap mean gene effect

0.02

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• hormone catabolic process
• peptide catabolic process
• proteolysis

Molecular functions

• metallocarboxypeptidase activity
• zinc ion binding

Cellular components

• extracellular space

Protein domainsUniProt · Pfam · InterPro

• Peptidase M14, carboxypeptidase A
• Carboxypeptidase, activation peptide
• Carboxypeptidase A, carboxypeptidase domain
• Metallocarboxypeptidase-like, propeptide
• Zinc carboxypeptidases, zinc-binding region 1
• Zinc carboxypeptidases, zinc-binding region 2
• Zinc carboxypeptidase
• Carboxypeptidase activation peptide

KeywordsUniProt

• Carboxypeptidase
• Disulfide bond
• Glycoprotein
• Hydrolase
• Metal-binding
• Metalloprotease
• Protease
• Secreted
• Signal
• Zinc
• Zymogen

InteractionsUniProt · HPA

Protein binding partners of CPA4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• LXN