Seroatlas · Human Serome Atlas

LRRTM1

Leucine-rich repeat transmembrane neuronal protein 1

Also known as: FLJ32082, LRRT1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86UE6
Gene
LRRTM1
Ensembl
ENSG00000162951
Chromosome
2
Canonical length
522 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Golgi apparatus

OverviewNCBI Gene

Predicted to be involved in regulation of postsynaptic density assembly and regulation of presynapse assembly. Predicted to act upstream of or within several processes, including long-term synaptic potentiation; negative regulation of receptor internalization; and positive regulation of synapse assembly. Located in endoplasmic reticulum and growth cone. Is active in GABA-ergic synapse and postsynaptic specialization membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

522 residues, UniProt reviewed canonical sequence.

>Q86UE6|LRRTM1
     1  MDFLLLGLCL YWLLRRPSGV VLCLLGACFQ MLPAAPSGCP QLCRCEGRLL YCEALNLTEA
    61  PHNLSGLLGL SLRYNSLSEL RAGQFTGLMQ LTWLYLDHNH ICSVQGDAFQ KLRRVKELTL
   121  SSNQITQLPN TTFRPMPNLR SVDLSYNKLQ ALAPDLFHGL RKLTTLHMRA NAIQFVPVRI
   181  FQDCRSLKFL DIGYNQLKSL ARNSFAGLFK LTELHLEHND LVKVNFAHFP RLISLHSLCL
   241  RRNKVAIVVS SLDWVWNLEK MDLSGNEIEY MEPHVFETVP HLQSLQLDSN RLTYIEPRIL
   301  NSWKSLTSIT LAGNLWDCGR NVCALASWLN NFQGRYDGNL QCASPEYAQG EDVLDAVYAF
   361  HLCEDGAEPT SGHLLSAVTN RSDLGPPASS ATTLADGGEG QHDGTFEPAT VALPGGEHAE
   421  NAVQIHKVVT GTMALIFSFL IVVLVLYVSW KCFPASLRQL RQCFVTQRRK QKQKQTMHQM
   481  AAMSAQEYYV DYKPNHIEGA LVIINEYGSC TCHQQPAREC EV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRTM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
22 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 22 nTPM
  • hippocampal formation: 13 nTPM
  • salivary gland: 12 nTPM
  • cerebral cortex: 12 nTPM
  • hypothalamus: 8 nTPM
  • amygdala: 7.2 nTPM

Single-cell type

  • epididymal efferent duct absorptive cells: 24 nCPM
  • schwann cells: 19 nCPM
  • brain inhibitory neurons: 19 nCPM
  • müller glia: 16 nCPM
  • retinal ganglion cells: 16 nCPM
  • other brain neurons: 12 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • thalamus: 65 nTPM
  • hippocampal formation: 52 nTPM
  • basal ganglia: 46 nTPM
  • cerebral cortex: 38 nTPM
  • midbrain: 35 nTPM
  • amygdala: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.49
gnomAD pLI
0.59
gnomAD missense Z
1.42
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LRRTM1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRTM1 as an antibody target. Whether an autoantibody or antibody against LRRTM1 could matter depends on whether native LRRTM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRTM1 is annotated at the cell surface, where native LRRTM1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LRRTM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LRRTM1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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