Seroatlas · Human Serome Atlas

LRATD2

Protein LRATD2

Also known as: BCMP101, FAM84B, LRAT2_HUMAN, NSE2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96KN1
Gene: LRATD2
Ensembl: ENSG00000168672
Chromosome: 8
Canonical length: 310 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

310 residues, UniProt reviewed canonical sequence.

>Q96KN1|LRATD2
     1  MGNQVEKLTH LSYKEVPTAD PTGVDRDDGP RIGVSYIFSN DDEDVEPQPP PQGPDGGGLP
    61  DGGDGPPPPQ PQPYDPRLHE VECSVFYRDE CIYQKSFAPG SAALSTYTPE NLLNKCKPGD
   121  LVEFVSQAQY PHWAVYVGNF QVVHLHRLEV INSFLTDASQ GRRGRVVNDL YRYKPLSSSA
   181  VVRNALAHVG AKERELSWRN SESFAAWCRY GKREFKIGGE LRIGKQPYRL QIQLSAQRSH
   241  TLEFQSLEDL IMEKRRNDQI GRAAVLQELA THLHPAEPEE GDSNVARTTP PPGRPPAPSS
   301  EEEDGEAVAH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRATD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 41 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 41 nTPM
kidney: 26 nTPM
choroid plexus: 21 nTPM
esophagus: 18 nTPM
retina: 18 nTPM
stomach: 17 nTPM

Single-cell type

endometrial glandular cells: 293 nCPM
breast lactating cells: 140 nCPM
esophageal apical cells: 105 nCPM
endometrial luminal cells: 104 nCPM
parietal cells: 99 nCPM
retinal pigment epithelial cells: 85 nCPM

Immune cell

memory CD8 T-cell: 2.7 nTPM
T-reg: 2.6 nTPM
naive CD8 T-cell: 2.1 nTPM
naive CD4 T-cell: 2 nTPM
memory CD4 T-cell: 1.8 nTPM
basophil: 1.7 nTPM

Brain region

choroid plexus: 53 nTPM
white matter: 26 nTPM
medulla oblongata: 19 nTPM
midbrain: 16 nTPM
cerebellum: 15 nTPM
hypothalamus: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.45
gnomAD pLI: 0
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

InteractionsUniProt · HPA

Protein binding partners of LRATD2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRATD2 as an antibody target. Whether an autoantibody or antibody against LRATD2 could matter depends on whether native LRATD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRATD2 is annotated at the cell surface, where native LRATD2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LRATD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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