LNPEP

Protein identityUniProt · HPA

UniProt accession

Q9UIQ6

Gene

LNPEP

Ensembl

ENSG00000113441

Chromosome

5

Canonical length

1025 aa

Protein class

Enzymes, Predicted membrane proteins

Secretome location

Intracellular and membrane

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1025 residues, UniProt reviewed canonical sequence.

>Q9UIQ6|LNPEP
     1  MEPFTNDRLQ LPRNMIENSM FEEEPDVVDL AKEPCLHPLE PDEVEYEPRG SRLLVRGLGE
    61  HEMEEDEEDY ESSAKLLGMS FMNRSSGLRN SATGYRQSPD GACSVPSART MVVCAFVIVV
   121  AVSVIMVIYL LPRCTFTKEG CHKKNQSIGL IQPFATNGKL FPWAQIRLPT AVVPLRYELS
   181  LHPNLTSMTF RGSVTISVQA LQVTWNIILH STGHNISRVT FMSAVSSQEK QAEILEYAYH
   241  GQIAIVAPEA LLAGHNYTLK IEYSANISSS YYGFYGFSYT DESNEKKYFA ATQFEPLAAR
   301  SAFPCFDEPA FKATFIIKII RDEQYTALSN MPKKSSVVLD DGLVQDEFSE SVKMSTYLVA
   361  FIVGEMKNLS QDVNGTLVSI YAVPEKIGQV HYALETTVKL LEFFQNYFEI QYPLKKLDLV
   421  AIPDFEAGAM ENWGLLTFRE ETLLYDSNTS SMADRKLVTK IIAHELAHQW FGNLVTMKWW
   481  NDLWLNEGFA TFMEYFSLEK IFKELSSYED FLDARFKTMK KDSLNSSHPI SSSVQSSEQI
   541  EEMFDSLSYF KGSSLLLMLK TYLSEDVFQH AVVLYLHNHS YASIQSDDLW DSFNEVTNQT
   601  LDVKRMMKTW TLQKGFPLVT VQKKGKELFI QQERFFLNMK PEIQPSDTSY LWHIPLSYVT
   661  EGRNYSKYQS VSLLDKKSGV INLTEEVLWV KVNINMNGYY IVHYADDDWE ALIHQLKINP
   721  YVLSDKDRAN LINNIFELAG LGKVPLKRAF DLINYLGNEN HTAPITEALF QTDLIYNLLE
   781  KLGYMDLASR LVTRVFKLLQ NQIQQQTWTD EGTPSMRELR SALLEFACTH NLGNCSTTAM
   841  KLFDDWMASN GTQSLPTDVM TTVFKVGAKT DKGWSFLLGK YISIGSEAEK NKILEALASS
   901  EDVRKLYWLM KSSLNGDNFR TQKLSFIIRT VGRHFPGHLL AWDFVKENWN KLVQKFPLGS
   961  YTIQNIVAGS TYLFSTKTHL SEVQAFFENQ SEATFRLRCV QEALEVIQLN IQWMEKNLKS
  1021  LTWWL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LNPEP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.26

Highest tissue expression

18 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.25

gnomAD pLI

1

gnomAD missense Z

1.44

DepMap mean gene effect

-0.05

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell-cell signaling
• female pregnancy
• negative regulation of cold-induced thermogenesis
• neuropeptide catabolic process
• protein catabolic process
• protein polyubiquitination
• proteolysis
• regulation of blood pressure
• antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent

Molecular functions

• aminopeptidase activity
• metalloaminopeptidase activity
• metallopeptidase activity
• zinc ion binding

Cellular components

• cytoplasmic vesicle membrane
• cytosol
• early endosome lumen
• extracellular region
• lysosomal membrane
• membrane
• perinuclear region of cytoplasm
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
• Peptidase M1, membrane alanine aminopeptidase
• ERAP1-like C-terminal domain
• Peptidase M4/M1, CTD superfamily
• Aminopeptidase N-type
• Aminopeptidase N-like , N-terminal domain superfamliy
• Aminopeptidase N-like , N-terminal domain
• Peptidase M1 family aminopeptidases
• Peptidase family M1 domain
• ERAP1-like C-terminal domain
• Peptidase M1 N-terminal domain

KeywordsUniProt

• Acetylation
• Aminopeptidase
• Cell membrane
• Glycoprotein
• Hydrolase
• Membrane
• Metal-binding
• Metalloprotease
• Phosphoprotein
• Protease
• Secreted
• Signal-anchor
• Transmembrane
• Transmembrane helix
• Zinc

InteractionsUniProt · HPA

Protein binding partners of LNPEP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CANX
• TNKS2