Seroatlas · Human Serome Atlas

LMNB2

Lamin-B2

Also known as: LMN2, LMNB2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q03252
Gene
LMNB2
Ensembl
ENSG00000176619
Chromosome
19
Canonical length
620 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nuclear membrane

OverviewNCBI Gene

This gene encodes a B type nuclear lamin. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Mutations in this gene are associated with acquired partial lipodystrophy. [provided by RefSeq, May 2012]

Canonical amino-acid sequenceUniProt

620 residues, UniProt reviewed canonical sequence.

>Q03252|LMNB2
     1  MSPPSPGRRR EQRRPRAAAT MATPLPGRAG GPATPLSPTR LSRLQEKEEL RELNDRLAHY
    61  IDRVRALELE NDRLLLKISE KEEVTTREVS GIKALYESEL ADARRVLDET ARERARLQIE
   121  IGKLRAELDE VNKSAKKREG ELTVAQGRVK DLESLFHRSE VELAAALSDK RGLESDVAEL
   181  RAQLAKAEDG HAVAKKQLEK ETLMRVDLEN RCQSLQEELD FRKSVFEEEV RETRRRHERR
   241  LVEVDSSRQQ EYDFKMAQAL EELRSQHDEQ VRLYKLELEQ TYQAKLDSAK LSSDQNDKAA
   301  SAAREELKEA RMRLESLSYQ LSGLQKQASA AEDRIRELEE AMAGERDKFR KMLDAKEQEM
   361  TEMRDVMQQQ LAEYQELLDV KLALDMEINA YRKLLEGEEE RLKLSPSPSS RVTVSRATSS
   421  SSGSLSATGR LGRSKRKRLE VEEPLGSGPS VLGTGTGGSG GFHLAQQASA SGSVSIEEID
   481  LEGKFVQLKN NSDKDQSLGN WRIKRQVLEG EEIAYKFTPK YILRAGQMVT VWAAGAGVAH
   541  SPPSTLVWKG QSSWGTGESF RTVLVNADGE EVAMRTVKKS SVMRENENGE EEEEEAEFGE
   601  EDLFHQQGDP RTTSRGCYVM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LMNB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
31 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 31 nTPM
  • thymus: 22 nTPM
  • cerebellum: 19 nTPM
  • bone marrow: 16 nTPM
  • appendix: 15 nTPM
  • skeletal muscle: 14 nTPM

Single-cell type

  • early spermatids: 310 nCPM
  • late primary spermatocytes: 129 nCPM
  • extravillous trophoblasts: 99 nCPM
  • esophageal basal cells: 55 nCPM
  • migrating cytotrophoblasts: 52 nCPM
  • monocyte progenitors: 46 nCPM

Immune cell

  • plasmacytoid DC: 3.5 nTPM
  • non-classical monocyte: 2.2 nTPM
  • MAIT T-cell: 1.6 nTPM
  • naive CD8 T-cell: 1.3 nTPM
  • memory CD4 T-cell: 1.1 nTPM
  • naive CD4 T-cell: 1.1 nTPM

Brain region

  • cerebellum: 19 nTPM
  • hypothalamus: 18 nTPM
  • thalamus: 15 nTPM
  • midbrain: 15 nTPM
  • amygdala: 14 nTPM
  • cerebral cortex: 14 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LMNB2.

Disease | AllUniProt

Conditions LMNB2 is implicated in, by any mechanism.

  • Partial acquired lipodystrophy (APLD) MIM:608709
  • Epilepsy, progressive myoclonic 9 (EPM9) MIM:616540
  • Microcephaly 27, primary, autosomal dominant (MCPH27) MIM:619180

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 688 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Microcephaly 27, primary, autosomal dominant
  • Progressive myoclonic epilepsy type 9
  • LMNB2-related disorder
  • See cases

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.1
gnomAD pLI
1
gnomAD missense Z
0.66
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LMNB2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LMNB2 as an antibody target. Whether an autoantibody or antibody against LMNB2 could matter depends on whether native LMNB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LMNB2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LMNB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LMNB2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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