Seroatlas · Human Serome Atlas

LIMCH1

LIM and calponin homology domains-containing protein 1

Also known as: DKFZP686A01247, LIMC1_HUMAN, LIMCH1A, LMO7B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UPQ0
Gene: LIMCH1
Ensembl: ENSG00000064042
Chromosome: 4
Canonical length: 1083 aa
Protein class: Predicted intracellular proteins
Subcellular location: Actin filaments

OverviewNCBI Gene

Enables myosin II head/neck binding activity. Involved in several processes, including cytoplasmic actin-based contraction involved in cell motility; positive regulation of stress fiber assembly; and regulation of focal adhesion assembly. Located in myosin II complex and stress fiber. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1083 residues, UniProt reviewed canonical sequence.

>Q9UPQ0|LIMCH1
     1  MACPALGLEA LQPLQPEPPP EPAFSEAQKW IEQVTGRSFG DKDFRTGLEN GILLCELLNA
    61  IKPGLVKKIN RLPTPIAGLD NIILFLRGCK ELGLKESQLF DPSDLQDTSN RVTVKSLDYS
   121  RKLKNVLVTI YWLGKAANSC TSYSGTTLNL KEFEGLLAQM RKDTDDIESP KRSIRDSGYI
   181  DCWDSERSDS LSPPRHGRDD SFDSLDSFGS RSRQTPSPDV VLRGSSDGRG SDSESDLPHR
   241  KLPDVKKDDM SARRTSHGEP KSAVPFNQYL PNKSNQTAYV PAPLRKKKAE REEYRKSWST
   301  ATSPLGGERP FRYGPRTPVS DDAESTSMFD MRCEEEAAVQ PHSRARQEQL QLINNQLREE
   361  DDKWQDDLAR WKSRRRSVSQ DLIKKEEERK KMEKLLAGED GTSERRKSIK TYREIVQEKE
   421  RRERELHEAY KNARSQEEAE GILQQYIERF TISEAVLERL EMPKILERSH STEPNLSSFL
   481  NDPNPMKYLR QQSLPPPKFT ATVETTIARA SVLDTSMSAG SGSPSKTVTP KAVPMLTPKP
   541  YSQPKNSQDV LKTFKVDGKV SVNGETVHRE EEKERECPTV APAHSLTKSQ MFEGVARVHG
   601  SPLELKQDNG SIEINIKKPN SVPQELAATT EKTEPNSQED KNDGGKSRKG NIELASSEPQ
   661  HFTTTVTRCS PTVAFVEFPS SPQLKNDVSE EKDQKKPENE MSGKVELVLS QKVVKPKSPE
   721  PEATLTFPFL DKMPEANQLH LPNLNSQVDS PSSEKSPVMT PQFKFWAWDP EEERRRQEKW
   781  QQEQERLLQE RYQKEQDKLK EEWEKAQKEV EEEERRYYEE ERKIIEDTVV PFTVSSSSAD
   841  QLSTSSSMTE GSGTMNKIDL GNCQDEKQDR RWKKSFQGDD SDLLLKTRES DRLEEKGSLT
   901  EGALAHSGNP VSKGVHEDHQ LDTEAGAPHC GTNPQLAQDP SQNQQTSNPT HSSEDVKPKT
   961  LPLDKSINHQ IESPSERRKK SPREHFQAGP FSPCSPTPPG QSPNRSISGK KLCSSCGLPL
  1021  GKGAAMIIET LNLYFHIQCF RCGICKGQLG DAVSGTDVRI RNGLLNCNDC YMRSRSAGQP
  1081  TTL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LIMCH1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 259 nTPM

Expression across tissuesHPA

Tissue

tongue: 259 nTPM
skeletal muscle: 191 nTPM
lung: 115 nTPM
spleen: 102 nTPM
heart muscle: 90 nTPM
spinal cord: 89 nTPM

Single-cell type

alveolar cells type 1: 1,912 nCPM
transitional alveolar cells: 1,343 nCPM
oligodendrocytes: 1,182 nCPM
prostatic glandular cells: 1,163 nCPM
renal connecting tubule cells: 1,117 nCPM
myonuclei: 1,086 nCPM

Immune cell

myeloid DC: 1.3 nTPM
classical monocyte: 0.1 nTPM
basophil: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

white matter: 273 nTPM
basal ganglia: 229 nTPM
midbrain: 218 nTPM
medulla oblongata: 207 nTPM
spinal cord: 195 nTPM
cerebellum: 195 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.31
gnomAD pLI: 0.95
gnomAD missense Z: 0.52
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

actin binding
metal ion binding
myosin II head/neck binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LIMCH1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

MYH9

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LIMCH1 as an antibody target. Whether an autoantibody or antibody against LIMCH1 could matter depends on whether native LIMCH1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LIMCH1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LIMCH1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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