Seroatlas · Human Serome Atlas

LIM2

Lens fiber membrane intrinsic protein

Also known as: LMIP_HUMAN, MP17, MP19

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P55344
Gene
LIM2
Ensembl
ENSG00000105370
Chromosome
19
Canonical length
173 aa
Protein class
Disease related genes, Human disease related genes, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes an eye lens-specific protein found at the junctions of lens fiber cells, where it may contribute to cell junctional organization. It acts as a receptor for calmodulin, and may play an important role in both lens development and cataractogenesis. Mutations in this gene have been associated with cataract formation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

Canonical amino-acid sequenceUniProt

173 residues, UniProt reviewed canonical sequence.

>P55344|LIM2
     1  MYSFMGGGLF CAWVGTILLV VAMATDHWMQ YRLSGSFAHQ GLWRYCLGNK CYLQTDSIAY
    61  WNATRAFMIL SALCAISGII MGIMAFAHQP TFSRISRPFS AGIMFFSSTL FVVLALAIYT
   121  GVTVSFLGRR FGDWRFSWSY ILGWVAVLMT FFAGIFYMCA YRVHECRRLS TPR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LIM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
0.5 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 0.5 nTPM
  • lung: 0.2 nTPM
  • spleen: 0.2 nTPM
  • testis: 0.2 nTPM
  • duodenum: 0.1 nTPM
  • adipose tissue: 0 nTPM

Single-cell type

  • nk-cells: 4.7 nCPM
  • neutrophils: 1.8 nCPM
  • esophageal apical cells: 1.4 nCPM
  • late primary spermatocytes: 1.4 nCPM
  • early spermatids: 1.2 nCPM
  • esophageal suprabasal cells: 0.7 nCPM

Immune cell

  • gdT-cell: 11 nTPM
  • total PBMC: 1.9 nTPM
  • NK-cell: 1.5 nTPM
  • MAIT T-cell: 1.4 nTPM
  • naive CD8 T-cell: 1.3 nTPM
  • memory CD8 T-cell: 0.3 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LIM2.

Disease | AllUniProt

Conditions LIM2 is implicated in, by any mechanism.

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 113 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Cataract 19 multiple types
  • Cataract
  • LIM2-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.28
gnomAD pLI
0
gnomAD missense Z
-0.67
DepMap mean gene effect
0.12
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LIM2 as an antibody target. Whether an autoantibody or antibody against LIM2 could matter depends on whether native LIM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LIM2 is annotated at the cell surface, where native LIM2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LIM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LIM2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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