LILRB2

Protein identityUniProt · HPA

UniProt accession

Q8N423

Gene

LILRB2

Ensembl

ENSG00000131042

Chromosome

19

Canonical length

597 aa

Protein class

CD markers, Predicted membrane proteins

OverviewNCBI Gene

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

597 residues, UniProt reviewed canonical sequence.

>Q8N423|LILRB2
     1  MTPIVTVLIC LGLSLGPRTR VQTGTIPKPT LWAEPDSVIT QGSPVTLSCQ GSLEAQEYRL
    61  YREKKSASWI TRIRPELVKN GQFHIPSITW EHTGRYGCQY YSRARWSELS DPLVLVMTGA
   121  YPKPTLSAQP SPVVTSGGRV TLQCESQVAF GGFILCKEGE DEHPQCLNSQ PHARGSSRAI
   181  FSVGPVSPNR RWSHRCYGYD LNSPYVWSSP SDLLELLVPG VSKKPSLSVQ PGPVMAPGES
   241  LTLQCVSDVG YDRFVLYKEG ERDLRQLPGR QPQAGLSQAN FTLGPVSRSY GGQYRCYGAH
   301  NLSSECSAPS DPLDILITGQ IRGTPFISVQ PGPTVASGEN VTLLCQSWRQ FHTFLLTKAG
   361  AADAPLRLRS IHEYPKYQAE FPMSPVTSAH AGTYRCYGSL NSDPYLLSHP SEPLELVVSG
   421  PSMGSSPPPT GPISTPGPED QPLTPTGSDP QSGLGRHLGV VIGILVAVVL LLLLLLLLFL
   481  ILRHRRQGKH WTSTQRKADF QHPAGAVGPE PTDRGLQWRS SPAADAQEEN LYAAVKDTQP
   541  EDGVEMDTRA AASEAPQDVT YAQLHSLTLR RKATEPPPSQ EREPPAEPSI YATLAIH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LILRB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.42

Highest tissue expression

49 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.12

gnomAD pLI

0

gnomAD missense Z

-2.3

DepMap mean gene effect

-0.07

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• adaptive immune response
• cell surface receptor signaling pathway
• cell-cell signaling
• cellular defense response
• cellular response to lipopolysaccharide
• Fc receptor mediated inhibitory signaling pathway
• heterotypic cell-cell adhesion
• immune response
• immune response-inhibiting cell surface receptor signaling pathway
• immune response-regulating signaling pathway
• interleukin-10-mediated signaling pathway
• learning or memory
• negative regulation of calcium ion transport
• negative regulation of postsynaptic density organization
• negative regulation of protein metabolic process
• negative regulation of T cell costimulation
• negative regulation of T cell proliferation
• positive regulation of interleukin-6 production
• positive regulation of long-term synaptic depression
• positive regulation of regulatory T cell differentiation
• positive regulation of T cell proliferation
• positive regulation of T cell tolerance induction
• positive regulation of tolerance induction
• regulation of dendritic cell differentiation
• regulation of long-term synaptic potentiation
• signal transduction
• negative regulation of antigen processing and presentation

Molecular functions

• amyloid-beta binding
• cell adhesion molecule binding
• inhibitory MHC class I receptor activity
• MHC class I protein binding
• MHC class Ib protein binding
• MHC class Ib protein complex binding
• protein homodimerization activity
• protein phosphatase 1 binding
• protein-containing complex binding

Cellular components

• cell surface
• cytoplasm
• extracellular space
• ficolin-1-rich granule membrane
• membrane
• plasma membrane
• tertiary granule membrane

Protein domainsUniProt · Pfam · InterPro

• Immunoglobulin subtype 2
• Immunoglobulin domain subtype
• Immunoglobulin-like domain
• Immunoglobulin-like beta-sandwich domain
• Immunoglobulin-like fold
• Immunoglobulin-like domain superfamily
• Immunoglobulin-like Receptors in Immune Regulation
• Immunoglobulin domain
• Immunoglobulin domain

KeywordsUniProt

• Adaptive immunity
• Alternative initiation
• Alternative promoter usage
• Cell membrane
• Disulfide bond
• Glycoprotein
• Immunity
• Immunoglobulin domain
• Membrane
• Phosphoprotein
• Receptor
• Repeat
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of LILRB2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PTPN6
• HLA-G