Seroatlas · Human Serome Atlas

LHFPL7

LHFPL tetraspan subfamily member 7 protein

Also known as: bA9F11.1, LHPL7_HUMAN, TMEM211

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ICI0
Gene: LHFPL7
Ensembl: ENSG00000206069
Chromosome: 22
Canonical length: 200 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

200 residues, UniProt reviewed canonical sequence.

>Q6ICI0|LHFPL7
     1  MLSSVWVALG LSLTCTSAFS LISPAWFQTP TFSFGILTYC SWPQGNSWNQ SCVTFSSLED
    61  IPDFAWKVSA VMLLGGWLLL AFNAIFLLSW AVAPKGLCPR RSSVPMPGVQ AVAATAMIVG
   121  LLIFPIGLAS PFIKEVCEAS SMYYGGKCRL GWGYMTAILN AVLASLLPII SWPHTTKVQG
   181  RTIIFSSATE RIIFVPEMNK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LHFPL7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 5.6 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 5.6 nTPM
stomach: 3.2 nTPM
cervix: 2.5 nTPM
skin: 1.1 nTPM
endometrium: 0.6 nTPM
breast: 0.4 nTPM

Single-cell type

parietal cells: 18 nCPM
salivary ionocytes: 16 nCPM
conjunctival goblet cells: 16 nCPM
submucosal glandular cells: 10 nCPM
salivary duct cells: 9.8 nCPM
respiratory secretory cells: 7.7 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 1.9 nTPM
basal ganglia: 1.6 nTPM
cerebral cortex: 1.5 nTPM
choroid plexus: 1.1 nTPM
amygdala: 1 nTPM
hippocampal formation: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.87
gnomAD pLI: 0.03
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LHFPL7 as an antibody target. Whether an autoantibody or antibody against LHFPL7 could matter depends on whether native LHFPL7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LHFPL7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LHFPL7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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