Seroatlas · Human Serome Atlas

LHFPL4

LHFPL tetraspan subfamily member 4 protein

Also known as: GARLH4, LHPL4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z7J7
Gene
LHFPL4
Ensembl
ENSG00000156959
Chromosome
3
Canonical length
247 aa
Protein class
Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

This gene is a member of the lipoma HMGIC fusion partner (LHFP) gene family, which is a subset of the superfamily of tetraspan transmembrane protein encoding genes. Mutations in one LHFP-like gene result in deafness in humans and mice, and a second LHFP-like gene is fused to a high-mobility group gene in a translocation-associated lipoma. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

247 residues, UniProt reviewed canonical sequence.

>Q7Z7J7|LHFPL4
     1  MLPSQEASKL YHEHYMRNSR AIGVLWAIFT ICFAIINVVV FIQPYWVGDS VSTPKPGYFG
    61  LFHYCVGSGL AGRELTCRGS FTDFSTIPSS AFKAAAFFVL LSMVLILGCI TCFSLFFFCN
   121  TATVYKICAW MQLLAALCLV LGCMIFPDGW DAETIRDMCG AKTGKYSLGD CSVRWAYILA
   181  IIGILNALIL SFLAFVLGNR QTDLLQEELK PENKDFVGST VSSVLRPGGD VSGWGVLPCP
   241  VAHSQGP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LHFPL4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 17 nTPM
  • cerebral cortex: 16 nTPM
  • hypothalamus: 14 nTPM
  • basal ganglia: 13 nTPM
  • pituitary gland: 12 nTPM
  • hippocampal formation: 11 nTPM

Single-cell type

  • retinal bipolar cells: 154 nCPM
  • cone photoreceptor cells: 130 nCPM
  • gonadotrophs: 111 nCPM
  • thyrotrophs: 107 nCPM
  • retinal amacrine cells: 105 nCPM
  • rod photoreceptor cells: 97 nCPM

Immune cell

  • plasmacytoid DC: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebral cortex: 40 nTPM
  • hypothalamus: 34 nTPM
  • basal ganglia: 31 nTPM
  • hippocampal formation: 30 nTPM
  • pons: 29 nTPM
  • amygdala: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.62
gnomAD pLI
0.65
gnomAD missense Z
2.1
DepMap mean gene effect
-0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LHFPL4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LHFPL4 as an antibody target. Whether an autoantibody or antibody against LHFPL4 could matter depends on whether native LHFPL4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LHFPL4 is annotated at the cell surface, where native LHFPL4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label LHFPL4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LHFPL4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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