LHFPL3
LHFPL tetraspan subfamily member 3 protein
Also known as: LHFPL4, LHPL3_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q86UP9
- Gene
- LHFPL3
- Ensembl
- ENSG00000187416
- Chromosome
- 7
- Canonical length
- 236 aa
- Protein class
- Predicted membrane proteins
- Subcellular location
- Vesicles
OverviewNCBI Gene
This gene is a member of the lipoma HMGIC fusion partner (LHFP) gene family, which is a subset of the superfamily of tetraspan transmembrane protein encoding genes. Mutations in one LHFP-like gene result in deafness in humans and mice, and a second LHFP-like gene is fused to a high-mobility group gene in a translocation-associated lipoma. A partial gene fragment named LHFPL4 corresponds to a portion of the first exon of this gene. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
236 residues, UniProt reviewed canonical sequence.
>Q86UP9|LHFPL3
1 MPGAAAAAAA AAAAMLPAQE AAKLYHTNYV RNSRAIGVLW AIFTICFAIV NVVCFIQPYW
61 IGDGVDTPQA GYFGLFHYCI GNGFSRELTC RGSFTDFSTL PSGAFKAASF FIGLSMMLII
121 ACIICFTLFF FCNTATVYKI CAWMQLTSAA CLVLGCMIFP DGWDSDEVKR MCGEKTDKYT
181 LGACSVRWAY ILAIIGILDA LILSFLAFVL GNRQDSLMAE ELKAENKVLL SQYSLELocalizationUniProt · AlphaFold · HPA
Whether an antibody against LHFPL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 4
- Mean surface accessibility (rSASA)
- 0.31
- Highest tissue expression
- 14 nTPM
Expression across tissuesHPA
Tissue
- cerebral cortex: 14 nTPM
- retina: 13 nTPM
- amygdala: 9.1 nTPM
- basal ganglia: 7.2 nTPM
- hippocampal formation: 7.2 nTPM
- hypothalamus: 6.7 nTPM
Single-cell type
- oligodendrocyte progenitor cells: 4,455 nCPM
- rod photoreceptor cells: 2,735 nCPM
- cone photoreceptor cells: 1,598 nCPM
- endometrial stromal cells: 673 nCPM
- brain inhibitory neurons: 598 nCPM
- decidual stromal cells: 531 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- thalamus: 47 nTPM
- amygdala: 35 nTPM
- hypothalamus: 29 nTPM
- midbrain: 26 nTPM
- cerebellum: 26 nTPM
- basal ganglia: 22 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.35
- gnomAD pLI
- 0.93
- gnomAD missense Z
- 1.06
- DepMap mean gene effect
- -0.01
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads LHFPL3 as an antibody target. Whether an autoantibody or antibody against LHFPL3 could matter depends on whether native LHFPL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
LHFPL3 is annotated at the cell surface, where native LHFPL3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label LHFPL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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