LGALSL
Galectin-related protein
Also known as: GRP, HSPC159, LEGL_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q3ZCW2
- Gene
- LGALSL
- Ensembl
- ENSG00000119862
- Chromosome
- 2
- Canonical length
- 172 aa
- Protein class
- Plasma proteins, Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
Predicted to enable carbohydrate binding activity. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
172 residues, UniProt reviewed canonical sequence.
>Q3ZCW2|LGALSL
1 MAGSVADSDA VVKLDDGHLN NSLSSPVQAD VYFPRLIVPF CGHIKGGMRP GKKVLVMGIV
61 DLNPESFAIS LTCGDSEDPP ADVAIELKAV FTDRQLLRNS CISGERGEEQ SAIPYFPFIP
121 DQPFRVEILC EHPRFRVFVD GHQLFDFYHR IQTLSAIDTI KINGDLQITK LGLocalizationUniProt · AlphaFold · HPA
Whether an antibody against LGALSL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.37
- Highest tissue expression
- 88 nTPM
Expression across tissuesHPA
Tissue
- skin: 88 nTPM
- retina: 84 nTPM
- skeletal muscle: 56 nTPM
- esophagus: 23 nTPM
- parathyroid gland: 18 nTPM
- tongue: 17 nTPM
Single-cell type
- platelets: 923 nCPM
- megakaryocytes: 631 nCPM
- ocular epithelial cells: 424 nCPM
- suprabasal keratinocytes: 171 nCPM
- breast secretory cells: 113 nCPM
- rod photoreceptor cells: 106 nCPM
Immune cell
- neutrophil: 1.6 nTPM
- eosinophil: 1.5 nTPM
- total PBMC: 1.4 nTPM
- MAIT T-cell: 0.7 nTPM
- classical monocyte: 0.1 nTPM
- memory B-cell: 0.1 nTPM
Brain region
- cerebellum: 19 nTPM
- choroid plexus: 17 nTPM
- hypothalamus: 17 nTPM
- basal ganglia: 16 nTPM
- cerebral cortex: 15 nTPM
- white matter: 12 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.04
- gnomAD pLI
- 0.02
- gnomAD missense Z
- 0.99
- DepMap mean gene effect
- -0.02
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads LGALSL as an antibody target. Whether an autoantibody or antibody against LGALSL could matter depends on whether native LGALSL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
LGALSL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label LGALSL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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