LGALS7
Galectin-7
Also known as: GAL7, LEG7_HUMAN, LGALS7A, LGALS7B, PIG1, TP53I1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P47929
- Gene
- LGALS7
- Ensembl
- ENSG00000205076
- Chromosome
- 19
- Canonical length
- 136 aa
- Protein class
- Plasma proteins, Predicted intracellular proteins
- Secretome location
- Intracellular and membrane
OverviewNCBI Gene
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Differential and in situ hybridization studies indicate that this lectin is specifically expressed in keratinocytes and found mainly in stratified squamous epithelium. A duplicate copy of this gene (GeneID:653499) is found adjacent to, but on the opposite strand on chromosome 19. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
136 residues, UniProt reviewed canonical sequence.
>P47929|LGALS7
1 MSNVPHKSSL PEGIRPGTVL RIRGLVPPNA SRFHVNLLCG EEQGSDAALH FNPRLDTSEV
61 VFNSKEQGSW GREERGPGVP FQRGQPFEVL IIASDDGFKA VVGDAQYHHF RHRLPLARVR
121 LVEVGGDVQL DSVRIFLocalizationUniProt · AlphaFold · HPA
Whether an antibody against LGALS7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.27
- Highest tissue expression
- 5,653 nTPM
Expression across tissuesHPA
Tissue
- skin: 5,653 nTPM
- esophagus: 1,182 nTPM
- vagina: 710 nTPM
- cervix: 402 nTPM
- salivary gland: 147 nTPM
- spleen: 21 nTPM
Single-cell type
- suprabasal keratinocytes: 1,307 nCPM
- basal keratinocytes: 320 nCPM
- esophageal suprabasal cells: 130 nCPM
- esophageal apical cells: 61 nCPM
- esophageal basal cells: 52 nCPM
- ocular epithelial cells: 23 nCPM
Immune cell
- gdT-cell: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- amygdala: 0.1 nTPM
- cerebral cortex: 0.1 nTPM
- hypothalamus: 0.1 nTPM
- white matter: 0.1 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.75
- gnomAD pLI
- 0.15
- gnomAD missense Z
- 1.45
- DepMap mean gene effect
- -0.01
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of LGALS7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads LGALS7 as an antibody target. Whether an autoantibody or antibody against LGALS7 could matter depends on whether native LGALS7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
LGALS7 is annotated as secreted, so native LGALS7 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label LGALS7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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