Seroatlas · Human Serome Atlas

LGALS16

Galectin-16

Also known as: LEG16_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A8MUM7
Gene
LGALS16
Ensembl
ENSG00000249861
Chromosome
19
Canonical length
142 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Enables lactose binding activity. Involved in positive regulation of T cell apoptotic process. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

142 residues, UniProt reviewed canonical sequence.

>A8MUM7|LGALS16
     1  MSFLTVPYKL PVSLSVGSCV IIKGTLIDSS INEPQLQVDF YTEMNEDSEI AFHLRVHLGR
    61  RVVMNSREFG IWMLEENLHY VPFEDGKPFD LRIYVCHNEY EVKVNGEYIY AFVHRIPPSY
   121  VKMIQVWRDV SLDSVLVNNG RR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LGALS16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
5.4 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 5.4 nTPM
  • cerebellum: 0.3 nTPM
  • retina: 0.3 nTPM
  • hypothalamus: 0.2 nTPM
  • cerebral cortex: 0.1 nTPM
  • midbrain: 0.1 nTPM

Single-cell type

  • syncytiotrophoblasts: 1,837 nCPM
  • migrating cytotrophoblasts: 15 nCPM
  • late spermatids: 5.2 nCPM
  • cytotrophoblasts: 4.8 nCPM
  • retinal horizontal cells: 2 nCPM
  • hofbauer cells: 1.9 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 1.1 nTPM
  • midbrain: 0.9 nTPM
  • medulla oblongata: 0.8 nTPM
  • cerebellum: 0.6 nTPM
  • pons: 0.5 nTPM
  • thalamus: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.77
gnomAD pLI
0
gnomAD missense Z
0.16
DepMap mean gene effect
-0.02
DepMap dependency class
selective

OntologyGO

Biological processes

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LGALS16 as an antibody target. Whether an autoantibody or antibody against LGALS16 could matter depends on whether native LGALS16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LGALS16 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LGALS16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LGALS16. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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