Seroatlas · Human Serome Atlas

LGALS14

Placental protein 13-like

Also known as: CLC2, PPL13, PPL13_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TCE9
Gene: LGALS14
Ensembl: ENSG00000006659
Chromosome: 19
Canonical length: 139 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene is predominantly expressed in placenta. The encoded protein belongs to the galectin (galaptin/S-lectin) family. The members of galectin family contain one or two carbohydrate recognition domains, which can bind beta-galactoside. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

139 residues, UniProt reviewed canonical sequence.

>Q8TCE9|LGALS14
     1  MSSLPVPYTL PVSLPVGSCV IITGTPILTF VKDPQLEVNF YTGMDEDSDI AFQFRLHFGH
    61  PAIMNSCVFG IWRYEEKCYY LPFEDGKPFE LCIYVRHKEY KVMVNGQRIY NFAHRFPPAS
   121  VKMLQVFRDI SLTRVLISD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LGALS14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 62 nTPM

Expression across tissuesHPA

Tissue

placenta: 62 nTPM
skin: 0.9 nTPM
tonsil: 0.6 nTPM
bone marrow: 0.5 nTPM
pancreas: 0.5 nTPM
lymph node: 0.4 nTPM

Single-cell type

syncytiotrophoblasts: 100 nCPM
migrating cytotrophoblasts: 16 nCPM
breast myoepithelial cells: 14 nCPM
cytotrophoblasts: 2.9 nCPM
late spermatids: 1.5 nCPM
endometrial glandular cells: 0.8 nCPM

Immune cell

naive CD4 T-cell: 0.6 nTPM
memory CD4 T-cell: 0.2 nTPM
neutrophil: 0.1 nTPM
total PBMC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

cerebellum: 11 nTPM
white matter: 10 nTPM
cerebral cortex: 9.6 nTPM
thalamus: 8.6 nTPM
pons: 8.4 nTPM
medulla oblongata: 8.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.53
gnomAD pLI: 0
gnomAD missense Z: -0.05
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LGALS14 as an antibody target. Whether an autoantibody or antibody against LGALS14 could matter depends on whether native LGALS14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LGALS14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LGALS14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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