Seroatlas · Human Serome Atlas

LGALS12

Galectin-12

Also known as: GRIP1, LEG12_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96DT0
Gene: LGALS12
Ensembl: ENSG00000133317
Chromosome: 11
Canonical length: 336 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

This gene encodes a member of the galectin superfamily, a group of beta-galactoside-binding proteins with conserved carbohydrate recognition domains. The related mouse protein is a primary regulator of the early stages of adipose tissue development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

336 residues, UniProt reviewed canonical sequence.

>Q96DT0|LGALS12
     1  MSQPSGGRAP GTRIYSWSCP TVMSPGEKLD PIPDSFILQP PVFHPVVPYV TTIFGGLHAG
    61  KMVMLQGVVP LDAHRFQVDF QCGCSLCPRP DIAFHFNPRF HTTKPHVICN TLHGGRWQRE
   121  ARWPHLALRR GSSFLILFLF GNEEVKVSVN GQHFLHFRYR LPLSHVDTLG IFGDILVEAV
   181  GFLNINPFVE GSREYPAGHP FLLMSPRLEV PCSHALPQGL SPGQVIIVRG LVLQEPKHFT
   241  VSLRDQAAHA PVTLRASFAD RTLAWISRWG QKKLISAPFL FYPQRFFEVL LLFQEGGLKL
   301  ALNGQGLGAT SMNQQALEQL RELRISGSVQ LYCVHS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LGALS12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 74 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 74 nTPM
breast: 40 nTPM
bone marrow: 17 nTPM
blood vessel: 13 nTPM
salivary gland: 4.2 nTPM
appendix: 2.5 nTPM

Single-cell type

platelets: 243 nCPM
adipocytes: 153 nCPM
neutrophil progenitors: 34 nCPM
mast cells: 13 nCPM
megakaryocytes: 12 nCPM
monocyte progenitors: 5.2 nCPM

Immune cell

eosinophil: 556 nTPM
classical monocyte: 28 nTPM
total PBMC: 17 nTPM
basophil: 16 nTPM
myeloid DC: 7.5 nTPM
neutrophil: 5.7 nTPM

Brain region

choroid plexus: 0.8 nTPM
white matter: 0.5 nTPM
medulla oblongata: 0.4 nTPM
amygdala: 0.3 nTPM
basal ganglia: 0.3 nTPM
cerebral cortex: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.59
gnomAD pLI: 0
gnomAD missense Z: -0.03
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

intrinsic apoptotic signaling pathway

Molecular functions

lactose binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LGALS12 as an antibody target. Whether an autoantibody or antibody against LGALS12 could matter depends on whether native LGALS12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LGALS12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LGALS12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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