Seroatlas · Human Serome Atlas

KRTAP26-1

Keratin-associated protein 26-1

Also known as: KR261_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6PEX3
Gene
KRTAP26-1
Ensembl
ENSG00000197683
Chromosome
21
Canonical length
210 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable structural molecule activity. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

210 residues, UniProt reviewed canonical sequence.

>Q6PEX3|KRTAP26-1
     1  MSCPNYCSGN SNSGSLRTSR HIPLTSIDLC PTSVSCGDVL YLPTSSQDHT WVTDNCQETC
    61  GEPTSCQPVH CETGNLETSC GSSTAYYVPR PCQGSSFLPA SFFSSSCLPV SCRPQRYVSS
   121  GCRPLRPLLN SYQPIGDCVP NAYRPQFCLS KSCQPQNLLT SGCQPSSCLA YRPQSLHVVS
   181  SSLRPLGPLF SGCQPLTHVF STCRPSCSGL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRTAP26-1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.73
Highest tissue expression
18 nTPM

Expression across tissuesHPA

Tissue

  • skin: 18 nTPM
  • placenta: 1.2 nTPM
  • adipose tissue: 0.4 nTPM
  • testis: 0.1 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM

Single-cell type

  • late spermatids: 0.9 nCPM
  • early spermatids: 0.5 nCPM
  • late primary spermatocytes: 0.1 nCPM
  • undifferentiated spermatogonia: 0.1 nCPM
  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 0.1 nTPM
  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.78
gnomAD pLI
0.14
gnomAD missense Z
0.18
DepMap mean gene effect
0.14
DepMap dependency class
none

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRTAP26-1 as an antibody target. Whether an autoantibody or antibody against KRTAP26-1 could matter depends on whether native KRTAP26-1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRTAP26-1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KRTAP26-1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KRTAP26-1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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