Seroatlas · Human Serome Atlas

KRTAP13-1

Keratin-associated protein 13-1

Also known as: KAP13.1, KR131_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IUC0
Gene
KRTAP13-1
Ensembl
ENSG00000198390
Chromosome
21
Canonical length
172 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Hair keratins and hair keratin-associated proteins (KAPs), such as KRTAP13-1, are the main structural proteins of hair fibers (Rogers et al., 2002 [PubMed 12359730]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

172 residues, UniProt reviewed canonical sequence.

>Q8IUC0|KRTAP13-1
     1  MSYNCCSGNF SSRSCGGYLH YPASSCGFSY PSNQVYSTDL CSPSTCQLGS SLYRGCQQTC
    61  WEPTSCQTSY VESSPCQTSC YRPRTSLLCS PCQTTYSGSL GFGSSSCRSL GYGSRSCYSV
   121  GCGSSGFRSL GYGGCGFPSL GYGVGFCRPT YLASRSCQSS CYRPTCGSGF YY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRTAP13-1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.74
Highest tissue expression
8.9 nTPM

Expression across tissuesHPA

Tissue

  • skin: 8.9 nTPM
  • salivary gland: 0.8 nTPM
  • testis: 0.2 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM

Single-cell type

  • early spermatids: 0.1 nCPM
  • late spermatids: 0.1 nCPM
  • respiratory ciliated cells: 0.1 nCPM
  • suprabasal keratinocytes: 0.1 nCPM
  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z
0.01
DepMap mean gene effect
0.01
DepMap dependency class
none

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRTAP13-1 as an antibody target. Whether an autoantibody or antibody against KRTAP13-1 could matter depends on whether native KRTAP13-1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRTAP13-1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KRTAP13-1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KRTAP13-1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...