Seroatlas · Human Serome Atlas

KRTAP11-1

Keratin-associated protein 11-1

Also known as: KAP11.1, KR111_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IUC1
Gene
KRTAP11-1
Ensembl
ENSG00000182591
Chromosome
21
Canonical length
163 aa
Protein class
Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable structural molecule activity. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

163 residues, UniProt reviewed canonical sequence.

>Q8IUC1|KRTAP11-1
     1  MSFNCSTRNC SSRPIGGRCI VPVAQVTTTS TTDADCLGGI CLPSSFQTGS WLLDHCQETC
    61  CEPTACQPTC YRRTSCVSNP CQVTCSRQTT CISNPCSTTY SRPLTFVSSG CQPLGGISSV
   121  CQPVGGISTV CQPVGGVSTV CQPACGVSRT YQQSCVSSCR RTC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRTAP11-1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.72
Highest tissue expression
187 nTPM

Expression across tissuesHPA

Tissue

  • skin: 187 nTPM
  • salivary gland: 4.8 nTPM
  • adipose tissue: 2.6 nTPM
  • testis: 0.1 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM

Single-cell type

  • suprabasal keratinocytes: 5.1 nCPM
  • cdc: 0.3 nCPM
  • microglia: 0.2 nCPM
  • basal keratinocytes: 0.1 nCPM
  • vascular smooth muscle cells: 0.1 nCPM
  • adipocytes: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • medulla oblongata: 0.5 nTPM
  • pons: 0.4 nTPM
  • thalamus: 0.3 nTPM
  • white matter: 0.3 nTPM
  • amygdala: 0.2 nTPM
  • basal ganglia: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.6
gnomAD pLI
0
gnomAD missense Z
0.73
DepMap mean gene effect
0.19
DepMap dependency class
none

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRTAP11-1 as an antibody target. Whether an autoantibody or antibody against KRTAP11-1 could matter depends on whether native KRTAP11-1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRTAP11-1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KRTAP11-1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KRTAP11-1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...