KRCC1
Lysine-rich coiled-coil protein 1
Also known as: FLJ22333, KRCC1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9NPI7
- Gene
- KRCC1
- Ensembl
- ENSG00000172086
- Chromosome
- 2
- Canonical length
- 259 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoli,Cytosol
OverviewNCBI Gene
No narrative summary is available for KRCC1 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
259 residues, UniProt reviewed canonical sequence.
>Q9NPI7|KRCC1
1 MKHSKKTYDS FQDELEDYIK VQKARGLEPK TCFRKMKGDY LETCGYKGEV NSRPTYRMFD
61 QRLPSETIQT YPRSCNIPQT VENRLPQWLP AHDSRLRLDS LSYCQFTRDC FSEKPVPLNF
121 NQQEYICGSH GVEHRVYKHF SSDNSTSTHQ ASHKQIHQKR KRHPEEGREK SEEERSKHKR
181 KKSCEEIDLD KHKSIQRKKT EVEIETVHVS TEKLKNRKEK KSRDVVSKKE ERKRTKKKKE
241 QGQERTEEEM LWDQSILGFLocalizationUniProt · AlphaFold · HPA
Whether an antibody against KRCC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.69
- Highest tissue expression
- 43 nTPM
Expression across tissuesHPA
Tissue
- colon: 43 nTPM
- rectum: 41 nTPM
- liver: 41 nTPM
- epididymis: 39 nTPM
- breast: 36 nTPM
- lymph node: 36 nTPM
Single-cell type
- esophageal apical cells: 458 nCPM
- colonocytes: 127 nCPM
- microglia: 119 nCPM
- esophageal suprabasal cells: 118 nCPM
- neutrophils: 110 nCPM
- neutrophil progenitors: 105 nCPM
Immune cell
- eosinophil: 78 nTPM
- basophil: 60 nTPM
- memory B-cell: 37 nTPM
- neutrophil: 36 nTPM
- T-reg: 34 nTPM
- naive B-cell: 33 nTPM
Brain region
- white matter: 23 nTPM
- medulla oblongata: 21 nTPM
- basal ganglia: 19 nTPM
- midbrain: 18 nTPM
- spinal cord: 17 nTPM
- pons: 17 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.28
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.7
- DepMap mean gene effect
- -0.01
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of KRCC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads KRCC1 as an antibody target. Whether an autoantibody or antibody against KRCC1 could matter depends on whether native KRCC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
KRCC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label KRCC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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