Seroatlas · Human Serome Atlas

KLF2

Krueppel-like factor 2

Also known as: KLF2_HUMAN, LKLF

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y5W3
Gene
KLF2
Ensembl
ENSG00000127528
Chromosome
19
Canonical length
355 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is expressed early in mammalian development and is found in many different cell types. The protein acts to bind the CACCC box found in the promoter of target genes to activate their transcription. It plays a role in many processes during development and disease including adipogenesis, embryonic erythropoiesis, epithelial integrity, inflammation and t-cell viability. [provided by RefSeq, Mar 2017]

Canonical amino-acid sequenceUniProt

355 residues, UniProt reviewed canonical sequence.

>Q9Y5W3|KLF2
     1  MALSEPILPS FSTFASPCRE RGLQERWPRA EPESGGTDDD LNSVLDFILS MGLDGLGAEA
    61  APEPPPPPPP PAFYYPEPGA PPPYSAPAGG LVSELLRPEL DAPLGPALHG RFLLAPPGRL
   121  VKAEPPEADG GGGYGCAPGL TRGPRGLKRE GAPGPAASCM RGPGGRPPPP PDTPPLSPDG
   181  PARLPAPGPR ASFPPPFGGP GFGAPGPGLH YAPPAPPAFG LFDDAAAAAA ALGLAPPAAR
   241  GLLTPPASPL ELLEAKPKRG RRSWPRKRTA THTCSYAGCG KTYTKSSHLK AHLRTHTGEK
   301  PYHCNWDGCG WKFARSDELT RHYRKHTGHR PFQCHLCDRA FSRSDHLALH MKRHM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.65
Highest tissue expression
139 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 139 nTPM
  • adipose tissue: 137 nTPM
  • blood vessel: 131 nTPM
  • heart muscle: 107 nTPM
  • lung: 104 nTPM
  • fallopian tube: 100 nTPM

Single-cell type

  • neutrophils: 1,080 nCPM
  • b-cells: 766 nCPM
  • plasma cells: 683 nCPM
  • vascular smooth muscle cells: 653 nCPM
  • vascular endothelial cells: 636 nCPM
  • smooth muscle cells: 628 nCPM

Immune cell

  • neutrophil: 80 nTPM
  • basophil: 64 nTPM
  • T-reg: 60 nTPM
  • memory CD4 T-cell: 57 nTPM
  • naive CD4 T-cell: 54 nTPM
  • naive B-cell: 48 nTPM

Brain region

  • midbrain: 80 nTPM
  • thalamus: 67 nTPM
  • medulla oblongata: 65 nTPM
  • amygdala: 59 nTPM
  • pons: 59 nTPM
  • basal ganglia: 55 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KLF2.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 66 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.71
gnomAD pLI
0.56
gnomAD missense Z
2.21
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KLF2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLF2 as an antibody target. Whether an autoantibody or antibody against KLF2 could matter depends on whether native KLF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLF2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KLF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KLF2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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