Seroatlas · Human Serome Atlas

KIR2DS5

Killer cell immunoglobulin-like receptor 2DS5

Also known as: KI2S5_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14953
Gene: KIR2DS5
Canonical length: 304 aa

OverviewNCBI Gene

No narrative summary is available for KIR2DS5 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

304 residues, UniProt reviewed canonical sequence.

>Q14953|KIR2DS5
     1  MSLMVISMAC VAFFLLQGAW PHEGFRRKPS LLAHPGPLVK SEETVILQCW SDVMFEHFLL
    61  HREGTFNHTL RLIGEHIDGV SKGNFSIGRM TQDLAGTYRC YGSVTHSPYQ LSAPSDPLDI
   121  VITGLYEKPS LSAQPGPTVL AGESVTLSCS SRSSYDMYHL SREGEAHERR LPAGPKVNRT
   181  FQADFPLDPA THGGTYRCFG SFRDSPYEWS KSSDPLLVSV TGNSSNSWPS PTEPSSETGN
   241  PRHLHVLIGT SVVKLPFTIL LFFLLHRWCS NKKNASVMDQ GPAGNRTVNR EDSDEQDHQE
   301  VSYA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIR2DS5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.41

OntologyGO

Biological processes

Molecular functions

HLA-C specific inhibitory MHC class I receptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KIR2DS5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TYROBP

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIR2DS5 as an antibody target. Whether an autoantibody or antibody against KIR2DS5 could matter depends on whether native KIR2DS5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIR2DS5 is annotated at the cell surface, where native KIR2DS5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KIR2DS5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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