Seroatlas · Human Serome Atlas

KICS2

KICSTOR subunit 2

Also known as: C12orf66, FLJ32549, KICS2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96MD2
Gene
KICS2
Ensembl
ENSG00000174206
Chromosome
12
Canonical length
445 aa
Protein class
Predicted intracellular proteins
Subcellular location
Lysosomes,Cytokinetic bridge

OverviewNCBI Gene

Involved in several processes, including cellular response to amino acid starvation; cellular response to glucose starvation; and negative regulation of TORC1 signaling. Located in intercellular bridge and lysosome. Part of KICSTOR complex. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

445 residues, UniProt reviewed canonical sequence.

>Q96MD2|KICS2
     1  MGESIPLAAP VPVEQAVLET FFSHLGIFSY DKAKDNVEKE REANKSAGGS WLSLLAALAH
    61  LAAAEKVYHS LTYLGQKLGG QSFFSRKDSI RTIYTSLHNE LKKVVTGRGA LGGTAPHVEE
   121  LLSHLSEQLC FFVQARMEIA DFYEKMYTLS TQKFINAEEL VGLLDAIMKK YSSRFHHPIL
   181  SPLESSFQLE VDVLCHLLKA QAQVSEWKFL PSLVNLHSAH TKLQTWGQIF EKQRETKKHL
   241  FGGQSQKAVQ PPHLFLWLMK LKNMLLAKFS FYFHEALSRQ TTASEMKTLT AKANPDFFGK
   301  ISSFIRKYDA ANVSLIFDNR GSESFQGHGY HHPHSYREAP KGVDQYPAVV SLPSDRPVMH
   361  WPNVIMIMTD RTSDLNSLEK VVHFYDDKVQ STYFLTRPEP HFTIVIIFES KKSERDSHFI
   421  SFLNEVSLAL KNPKVFASLK PGAKG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KICS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
8 nTPM

Expression across tissuesHPA

Tissue

  • liver: 8 nTPM
  • parathyroid gland: 5.3 nTPM
  • skin: 5.2 nTPM
  • thyroid gland: 5.2 nTPM
  • breast: 5.1 nTPM
  • kidney: 5.1 nTPM

Single-cell type

  • epididymal principal cells: 22 nCPM
  • epicardial cells: 18 nCPM
  • oligodendrocytes: 15 nCPM
  • hepatocytes: 14 nCPM
  • differentiating spermatogonia: 13 nCPM
  • cone photoreceptor cells: 12 nCPM

Immune cell

  • T-reg: 11 nTPM
  • naive CD4 T-cell: 8.8 nTPM
  • memory B-cell: 8.6 nTPM
  • naive CD8 T-cell: 8.4 nTPM
  • naive B-cell: 7.2 nTPM
  • memory CD4 T-cell: 6.4 nTPM

Brain region

  • white matter: 16 nTPM
  • basal ganglia: 13 nTPM
  • cerebral cortex: 12 nTPM
  • pons: 12 nTPM
  • midbrain: 12 nTPM
  • thalamus: 11 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KICS2.

Disease | AllUniProt

Conditions KICS2 is implicated in, by any mechanism.

  • Intellectual developmental disorder, autosomal recessive 83 (MRT83) MIM:621100

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 15 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Intellectual developmental disorder, autosomal recessive 83

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.55
gnomAD pLI
0.44
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • KICSTOR subunit 2
  • KICSTOR complex protein C12orf66-like, central domain superfamily
  • KICSTOR complex C12orf66 like

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KICS2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KICS2 as an antibody target. Whether an autoantibody or antibody against KICS2 could matter depends on whether native KICS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KICS2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KICS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KICS2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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