Seroatlas · Human Serome Atlas

ITFG2

KICSTOR complex protein ITFG2

Also known as: FGGAP1, ITFG2_HUMAN, KICS3, MDS028

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q969R8
Gene
ITFG2
Ensembl
ENSG00000111203
Chromosome
12
Canonical length
447 aa
Protein class
Predicted intracellular proteins
Subcellular location
Golgi apparatus,Vesicles

OverviewNCBI Gene

Involved in cellular response to amino acid starvation; cellular response to glucose starvation; and negative regulation of TORC1 signaling. Located in Golgi apparatus and lysosomal membrane. Part of KICSTOR complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

447 residues, UniProt reviewed canonical sequence.

>Q969R8|ITFG2
     1  MRSVSYVQRV ALEFSGSLFP HAICLGDVDN DTLNELVVGD TSGKVSVYKN DDSRPWLTCS
    61  CQGMLTCVGV GDVCNKGKNL LVAVSAEGWF HLFDLTPAKV LDASGHHETL IGEEQRPVFK
   121  QHIPANTKVM LISDIDGDGC RELVVGYTDR VVRAFRWEEL GEGPEHLTGQ LVSLKKWMLE
   181  GQVDSLSVTL GPLGLPELMV SQPGCAYAIL LCTWKKDTGS PPASEGPTDG SRETPAARDV
   241  VLHQTSGRIH NKNVSTHLIG NIKQGHGTES SGSGLFALCT LDGTLKLMEE MEEADKLLWS
   301  VQVDHQLFAL EKLDVTGNGH EEVVACAWDG QTYIIDHNRT VVRFQVDENI RAFCAGLYAC
   361  KEGRNSPCLV YVTFNQKIYV YWEVQLERME STNLVKLLET KPEYHSLLQE LGVDPDDLPV
   421  TRALLHQTLY HPDQPPQCAP SSLQDPT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ITFG2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 26 nTPM
  • thyroid gland: 25 nTPM
  • ovary: 23 nTPM
  • pancreas: 21 nTPM
  • cervix: 18 nTPM
  • endometrium: 18 nTPM

Single-cell type

  • choroid plexus epithelial cells: 168 nCPM
  • cardiomyocytes: 145 nCPM
  • myonuclei: 134 nCPM
  • thyrotrophs: 108 nCPM
  • rod photoreceptor cells: 99 nCPM
  • somatotrophs: 97 nCPM

Immune cell

  • non-classical monocyte: 36 nTPM
  • memory B-cell: 26 nTPM
  • naive B-cell: 24 nTPM
  • NK-cell: 23 nTPM
  • intermediate monocyte: 22 nTPM
  • naive CD4 T-cell: 20 nTPM

Brain region

  • white matter: 25 nTPM
  • choroid plexus: 24 nTPM
  • cerebellum: 22 nTPM
  • cerebral cortex: 21 nTPM
  • hypothalamus: 20 nTPM
  • pons: 19 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ITFG2.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 97 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.95
gnomAD pLI
0
gnomAD missense Z
0.8
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ITFG2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ITFG2 as an antibody target. Whether an autoantibody or antibody against ITFG2 could matter depends on whether native ITFG2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ITFG2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ITFG2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ITFG2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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