Seroatlas · Human Serome Atlas

KCNK2

Potassium channel subfamily K member 2

Also known as: K2p2.1, KCNK2_HUMAN, TREK-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95069
Gene
KCNK2
Ensembl
ENSG00000082482
Chromosome
1
Canonical length
426 aa
Protein class
FDA approved drug targets, Predicted membrane proteins, Voltage-gated ion channels
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes one of the members of the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential. The channel can be opened, however, by certain anesthetics, membrane stretching, intracellular acidosis, and heat. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

426 residues, UniProt reviewed canonical sequence.

>O95069|KCNK2
     1  MLPSASRERP GYRAGVAAPD LLDPKSAAQN SKPRLSFSTK PTVLASRVES DTTINVMKWK
    61  TVSTIFLVVV LYLIIGATVF KALEQPHEIS QRTTIVIQKQ TFISQHSCVN STELDELIQQ
   121  IVAAINAGII PLGNTSNQIS HWDLGSSFFF AGTVITTIGF GNISPRTEGG KIFCIIYALL
   181  GIPLFGFLLA GVGDQLGTIF GKGIAKVEDT FIKWNVSQTK IRIISTIIFI LFGCVLFVAL
   241  PAIIFKHIEG WSALDAIYFV VITLTTIGFG DYVAGGSDIE YLDFYKPVVW FWILVGLAYF
   301  AAVLSMIGDW LRVISKKTKE EVGEFRAHAA EWTANVTAEF KETRRRLSVE IYDKFQRATS
   361  IKRKLSAELA GNHNQELTPC RRTLSVNHLT SERDVLPPLL KTESIYLNGL TPHCAGEEIA
   421  VIENIK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCNK2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
50 nTPM

Expression across tissuesHPA

Tissue

  • adrenal gland: 50 nTPM
  • thyroid gland: 9 nTPM
  • breast: 6.1 nTPM
  • basal ganglia: 5.9 nTPM
  • cerebral cortex: 5 nTPM
  • amygdala: 4.1 nTPM

Single-cell type

  • adrenal cortex cells: 288 nCPM
  • gastric chief cells: 60 nCPM
  • brain inhibitory neurons: 59 nCPM
  • oligodendrocyte progenitor cells: 54 nCPM
  • fibroblasts: 45 nCPM
  • mucous neck cells: 45 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • basal ganglia: 25 nTPM
  • hypothalamus: 23 nTPM
  • thalamus: 20 nTPM
  • cerebral cortex: 19 nTPM
  • hippocampal formation: 15 nTPM
  • amygdala: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.68
gnomAD pLI
0.02
gnomAD missense Z
2.31
DepMap mean gene effect
0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KCNK2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCNK2 as an antibody target. Whether an autoantibody or antibody against KCNK2 could matter depends on whether native KCNK2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCNK2 is annotated at the cell surface, where native KCNK2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KCNK2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KCNK2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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