Seroatlas · Human Serome Atlas

KCNJ16

Inward rectifier potassium channel 16

Also known as: BIR9, KCJ16_HUMAN, Kir5.1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NPI9
Gene
KCNJ16
Ensembl
ENSG00000153822
Chromosome
17
Canonical length
418 aa
Protein class
Disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels
Subcellular location
Vesicles

OverviewNCBI Gene

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which tends to allow potassium to flow into rather than out of a cell, can form heterodimers with two other inward-rectifier type potassium channels. It may function in fluid and pH balance regulation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2014]

Canonical amino-acid sequenceUniProt

418 residues, UniProt reviewed canonical sequence.

>Q9NPI9|KCNJ16
     1  MSYYGSSYHI INADAKYPGY PPEHIIAEKR RARRRLLHKD GSCNVYFKHI FGEWGSYVVD
    61  IFTTLVDTKW RHMFVIFSLS YILSWLIFGS VFWLIAFHHG DLLNDPDITP CVDNVHSFTG
   121  AFLFSLETQT TIGYGYRCVT EECSVAVLMV ILQSILSCII NTFIIGAALA KMATARKRAQ
   181  TIRFSYFALI GMRDGKLCLM WRIGDFRPNH VVEGTVRAQL LRYTEDSEGR MTMAFKDLKL
   241  VNDQIILVTP VTIVHEIDHE SPLYALDRKA VAKDNFEILV TFIYTGDSTG TSHQSRSSYV
   301  PREILWGHRF NDVLEVKRKY YKVNCLQFEG SVEVYAPFCS AKQLDWKDQQ LHIEKAPPVR
   361  ESCTSDTKAR RRSFSAVAIV SSCENPEETT TSATHEYRET PYQKALLTLN RISVESQM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCNJ16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
252 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 252 nTPM
  • kidney: 182 nTPM
  • thyroid gland: 130 nTPM
  • pancreas: 41 nTPM
  • stomach: 22 nTPM
  • seminal vesicle: 21 nTPM

Single-cell type

  • distal convoluted tubule cells: 1,337 nCPM
  • renal connecting tubule cells: 765 nCPM
  • proximal tubule cells: 681 nCPM
  • renal collecting duct principal cells: 554 nCPM
  • loop of henle epithelial cells: 481 nCPM
  • parietal cells: 221 nCPM

Immune cell

  • neutrophil: 1.6 nTPM
  • gdT-cell: 0.3 nTPM
  • MAIT T-cell: 0.3 nTPM
  • memory B-cell: 0.3 nTPM
  • memory CD4 T-cell: 0.3 nTPM
  • naive B-cell: 0.3 nTPM

Brain region

  • medulla oblongata: 86 nTPM
  • hypothalamus: 86 nTPM
  • midbrain: 81 nTPM
  • spinal cord: 66 nTPM
  • pons: 56 nTPM
  • cerebellum: 50 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KCNJ16.

Disease | AllUniProt

Conditions KCNJ16 is implicated in, by any mechanism.

  • Hypokalemic tubulopathy and deafness (HKTD) MIM:619406

Disease | GeneticClinVar

13 pathogenic / likely-pathogenic of 43 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Hypokalemic tubulopathy and deafness
  • KCNJ16-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.67
gnomAD pLI
0
gnomAD missense Z
0
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCNJ16 as an antibody target. Whether an autoantibody or antibody against KCNJ16 could matter depends on whether native KCNJ16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCNJ16 is annotated at the cell surface, where native KCNJ16 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KCNJ16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KCNJ16. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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