Seroatlas · Human Serome Atlas

KCNJ15

ATP-sensitive inward rectifier potassium channel 15

Also known as: IRKK, KCJ15_HUMAN, Kir1.3, Kir4.2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q99712
Gene
KCNJ15
Ensembl
ENSG00000157551
Chromosome
21
Canonical length
375 aa
Protein class
FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Voltage-gated ion channels
Subcellular location
Vesicles,Plasma membrane,Cytosol

OverviewNCBI Gene

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Eight transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2013]

Canonical amino-acid sequenceUniProt

375 residues, UniProt reviewed canonical sequence.

>Q99712|KCNJ15
     1  MDAIHIGMSS TPLVKHTAGA GLKANRPRVM SKSGHSNVRI DKVDGIYLLY LQDLWTTVID
    61  MKWRYKLTLF AATFVMTWFL FGVIYYAIAF IHGDLEPGEP ISNHTPCIMK VDSLTGAFLF
   121  SLESQTTIGY GVRSITEECP HAIFLLVAQL VITTLIEIFI TGTFLAKIAR PKKRAETIKF
   181  SHCAVITKQN GKLCLVIQVA NMRKSLLIQC QLSGKLLQTH VTKEGERILL NQATVKFHVD
   241  SSSESPFLIL PMTFYHVLDE TSPLRDLTPQ NLKEKEFELV VLLNATVEST SAVCQSRTSY
   301  IPEEIYWGFE FVPVVSLSKN GKYVADFSQF EQIRKSPDCT FYCADSEKQQ LEEKYRQEDQ
   361  RERELRTLLL QQSNV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCNJ15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
225 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 225 nTPM
  • thyroid gland: 121 nTPM
  • pancreas: 55 nTPM
  • lung: 40 nTPM
  • stomach: 38 nTPM
  • gallbladder: 29 nTPM

Single-cell type

  • neutrophils: 2,665 nCPM
  • proximal tubule cells: 1,014 nCPM
  • renal connecting tubule cells: 436 nCPM
  • neutrophil progenitors: 206 nCPM
  • renal collecting duct principal cells: 187 nCPM
  • alveolar cells type 2: 165 nCPM

Immune cell

  • neutrophil: 398 nTPM
  • classical monocyte: 19 nTPM
  • total PBMC: 4.6 nTPM
  • myeloid DC: 1.2 nTPM
  • intermediate monocyte: 0.8 nTPM
  • plasmacytoid DC: 0.4 nTPM

Brain region

  • cerebral cortex: 16 nTPM
  • thalamus: 14 nTPM
  • pons: 6 nTPM
  • white matter: 4.6 nTPM
  • medulla oblongata: 4.2 nTPM
  • amygdala: 3.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.83
gnomAD pLI
0.11
gnomAD missense Z
1.18
DepMap mean gene effect
0.17
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KCNJ15 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCNJ15 as an antibody target. Whether an autoantibody or antibody against KCNJ15 could matter depends on whether native KCNJ15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCNJ15 is annotated at the cell surface, where native KCNJ15 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KCNJ15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KCNJ15. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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