Seroatlas · Human Serome Atlas

KCNJ14

ATP-sensitive inward rectifier potassium channel 14

Also known as: IRK4, KCJ14_HUMAN, Kir2.4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UNX9
Gene: KCNJ14
Ensembl: ENSG00000182324
Chromosome: 19
Canonical length: 436 aa
Protein class: FDA approved drug targets, Predicted membrane proteins, Voltage-gated ion channels

OverviewNCBI Gene

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel, and probably has a role in controlling the excitability of motor neurons. [provided by RefSeq, Feb 2013]

Canonical amino-acid sequenceUniProt

436 residues, UniProt reviewed canonical sequence.

>Q9UNX9|KCNJ14
     1  MGLARALRRL SGALDSGDSR AGDEEEAGPG LCRNGWAPAP VQSPVGRRRG RFVKKDGHCN
    61  VRFVNLGGQG ARYLSDLFTT CVDVRWRWMC LLFSCSFLAS WLLFGLAFWL IASLHGDLAA
   121  PPPPAPCFSH VASFLAAFLF ALETQTSIGY GVRSVTEECP AAVAAVVLQC IAGCVLDAFV
   181  VGAVMAKMAK PKKRNETLVF SENAVVALRD HRLCLMWRVG NLRRSHLVEA HVRAQLLQPR
   241  VTPEGEYIPL DHQDVDVGFD GGTDRIFLVS PITIVHEIDS ASPLYELGRA ELARADFELV
   301  VILEGMVEAT AMTTQCRSSY LPGELLWGHR FEPVLFQRGS QYEVDYRHFH RTYEVPGTPV
   361  CSAKELDERA EQASHSLKSS FPGSLTAFCY ENELALSCCQ EEDEDDETEE GNGVETEDGA
   421  ASPRVLTPTL ALTLPP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCNJ14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 54 nTPM

Expression across tissuesHPA

Tissue

retina: 54 nTPM
basal ganglia: 4.4 nTPM
skin: 2.1 nTPM
bone marrow: 1.9 nTPM
cerebral cortex: 1.7 nTPM
cerebellum: 1.6 nTPM

Single-cell type

rod photoreceptor cells: 214 nCPM
suprabasal keratinocytes: 16 nCPM
endometrial secretory cells: 15 nCPM
basal keratinocytes: 15 nCPM
ocular epithelial cells: 13 nCPM
paneth cells: 12 nCPM

Immune cell

basophil: 1 nTPM
neutrophil: 0.6 nTPM
memory B-cell: 0.3 nTPM
memory CD8 T-cell: 0.2 nTPM
naive B-cell: 0.2 nTPM
classical monocyte: 0.1 nTPM

Brain region

pons: 8.8 nTPM
cerebellum: 7.5 nTPM
thalamus: 7.3 nTPM
medulla oblongata: 7.2 nTPM
midbrain: 6.9 nTPM
basal ganglia: 6.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.57
gnomAD pLI: 0
gnomAD missense Z: 0.88
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

inward rectifier potassium channel activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCNJ14 as an antibody target. Whether an autoantibody or antibody against KCNJ14 could matter depends on whether native KCNJ14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCNJ14 is annotated at the cell surface, where native KCNJ14 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KCNJ14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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